Background Acute pain is a warning mechanism that exists to prevent tissue damage,
however pain can outlast its protective purpose and persist beyond injury, becoming …

Background Despite the increasing knowledge of the etiology of neuropathic pain, this type
of chronic pain is resistant to available analgesics in approximately 50% of patients and …

Resident macrophages are distributed across all tissues and are highly heterogeneous due
to adaptation to different tissue-specific environments. The resident macrophages of the …

Chemotherapy-induced peripheral neuropathy (CIPN) remains a pressing clinical problem;
however, our understanding of sexual dimorphism in CIPN remains unclear. Emerging …

Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been
extensively used in the clinic as the main cancer treatment either alone or as an adjuvant …

Earlier studies have demonstrated that essential fatty acid-derived specialized pro-resolving
mediators (SPMs) promote the resolution of inflammation and pain. However, the potential …

Brain cancer and leukemia are the most common cancers diagnosed in the pediatric
population and are often treated with lifesaving chemotherapy. However, chemotherapy …

Disclosures: K. Schroder reported" other" from Inflazome Ltd outside the submitted work; in
addition, K. Schroder had a patent to PCT/EP2017/053498 licensed (Inflazome Ltd), a patent …

Chemotherapy drugs such as vincristine (Vin) could cause neuropathic pain. However, it is
still lack of ideal therapeutic strategy to treat it. Mitochondrial dysfunction has been involved …

Pain is a persistent symptom of Rheumatoid Arthritis, and the K/BxN serum transfer model
recapitulates both association and dissociation between pain and joint inflammation in RA …