Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's
expressed genes and then transport and display this antigenic information on the cell …

Immunotherapy has become a key therapeutic strategy in the treatment of many cancers. As
a result, research efforts have been aimed at understanding mechanisms of resistance to …

Conditional gene expression has greatly facilitated the examination of the functions of
particular gene products. Using the Cre/lox P switching expression system, we plan to …

The prospect of transplanting cells and tissues without the risk of immune rejection or the
need for powerful immunosuppressive drugs is the 'holy grail'of transplantation medicine …

Publisher Summary It is known for some time that malignant transformation of human cells
may be associated with the appearance of tumor associated antigens (TAA). Decades of …

The idea that tumors must “escape” from immune recognition contains the implicit
assumption that tumors can be destroyed by immune responses either spontaneously or as …

In the past decade, basic studies in animal models have begun to elucidate the
physiological barriers which impede a successful antitumor immune response. These …

Given the vast number of genetic and epigenetic changes associated with carcinogenesis, it
is clear that tumors express many neoantigens. A central question in cancer immunology is …

HLA class I downregulation is a frequent event associated with tumour invasion and
development. Altered HLA class I tumour phenotypes can have profound effects on T-cell …

Oncogenic transformation in human and experimental animals is not necessarily followed by
the appearance of a tumor mass. The immune system of the host can recognize tumor …