Cisplatin is a highly effective antitumor agent whose clinical application is limited by the
inherent nephrotoxicity. The current measures of nephroprotection used in patients receiving …

Cisplatin (CDDP) has been widely used as a chemotherapeutic agent for solid tumors. The
most common side effect of CDDP is nephrotoxicity, and many efforts have been made in the …

AIMS: Cisplatin-induced nephrotoxicity is associated with increased oxidative stress and
inflammatory cytokines in the kidney. Epigallocatechin-3-gallate (EGCG) has anti-oxidant …

Cisplatin is a regularly employed effective chemotherapeutic agent for the treatment of many
types of cancer. The main drawback of cisplatin treatment is kidney toxicity which affects 25 …

Cisplatin is an effective anti-cancer drug; however, its clinical use is usually associated with
nephrotoxicity as a dose-limiting side effect. Several molecular mechanisms have been …

In previous studies, we have demonstrated the biological activity of thymoquinone (TQ), an
active compound extracted from the Nigella sativa plant, against cisplatin-induced …

ACE2 is a monocarboxypeptidase which generates Angiotensin (1–7) from Angiotensin II (1–
8). Attempts to target the kidney Renin Angiotensin System using native ACE2 to treat kidney …

Nephrotoxicity is a rapid deterioration of kidney function due to exposure to nephrotoxic
drugs as gentamicin. Gentamicin increases the generation of reactive oxygen species (ROS) …

It is documented that chronic renal diseases are gender related. The protective role of
angiotensin II receptor 1 (AT1) blocker losartan against cisplatin (CP)-induced nephrotoxicity …

Background Hyperthermic intraperitoneal chemotherapy (HIPEC) combined with
cytoreductive surgery (CRS) is the treatment of choice for selected patients with peritoneal …