Significance: A common link between all forms of acute and chronic kidney injuries,
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …

ROS are a group of small reactive molecules that play critical roles in the regulation of
various cell functions and biological processes. In the vascular system, physiological levels …

It has become clear that reactive oxygen species (ROS) contribute to the development of
hypertension via myriad effects. ROS are essential for normal cell function; however, they …

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …

Diabetic nephropathy is the major cause of end‐stage renal failure throughout the world in
both developed and developing countries. Diabetes affects all cell types of the kidney …

Diabetes mellitus is the most common cause of chronic renal disorders and end-stage
kidney disease in developed countries. It is the major cause of dialysis and transplantation …

Significance: Renal oxidative stress can be a cause, a consequence, or more often a
potentiating factor for hypertension. Increased reactive oxygen species (ROS) in the kidney …

Reelin was originally identified as a regulator of neuronal migration and synaptic function,
but its non-neuronal functions have received far less attention. Reelin participates in organ …

Glomerular podocytes are characterized by terminally differentiated epithelial cells with
limited proliferating ability; thus, podocyte loss could not be fully compensated by podocyte …

Vitamin D and its analogs have antiproteinuric activity and podocytes express the vitamin D
receptor, but whether vitamin D signaling in podocytes accounts for this renoprotection is …