Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Cancer cachexia is a disorder of energy balance characterized by the wasting of adipose
tissue and skeletal muscle resulting in severe weight loss with profound influence on …

The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has
reached pandemic levels worldwide and increased gradually. Most of them are listed on the …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Brain cell structure and function reflect neurodevelopment, plasticity, and aging; and
changes can help flag pathological processes such as neurodegeneration and …

Cachexia, a multifactorial wasting syndrome, is highly prevalent among advanced-stage
cancer patients. Unlike weight loss in healthy humans, the progressive loss of body weight …

The last decades revealed that the adipose tissue shows an unexplored therapeutic
potential. In particular, targeting the perivascular adipose tissue (PVAT), that surrounds …

Detection and differentiation of brown fat in humans poses several challenges, as this tissue
is sparse and often mixed with white adipose tissue. Non-invasive detection of beige fat …

Human thermogenic adipose tissue has long been touted as a promising therapeutic target
for obesity and its associated metabolic diseases. Here, we provide a brief overview of the …

Brown adipose tissue (BAT), a uniquely thermogenic tissue that plays an important role in
metabolism and energy expenditure, has recently become a revived target in the fight …