In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

The hallmark symptom of chronic heart failure (HF) is severe exercise intolerance. Impaired
perfusive and diffusive O2 transport are two of the major determinants of reduced physical …

Rationale: Abnormalities in nitric oxide signaling play a pivotal role in heart failure with
preserved ejection fraction (HFpEF). Intravenous sodium nitrite, which is converted to nitric …

Key points Oral consumption of nitrate (NO3−) in beetroot juice has been shown to decrease
the oxygen cost of submaximal exercise; however, the mechanism of action remains …

In 1867 the organic nitrite, amyl nitrite, was introduced as a therapeutic agent in the
treatment of angina pectoris and was later substituted by the organic nitrate nitroglycerin …

BACKGROUND. Pulmonary hypertension (PH) is associated with poor outcomes, yet
specific treatments only exist for a small subset of patients. The most common form of PH is …

Aims To determine whether inorganic nitrite improves peripheral and pulmonary oxygen
(O2) transport during exercise in heart failure with preserved ejection fraction (HFpEF) …

Endothelial dysfunction and reduced nitric oxide (NO) signaling are key abnormalities
leading to skeletal muscle oxygen delivery-utilization mismatch and poor physical capacity …

Medical practice is dogged by dogma. A conclusive evidence base is lacking for many
aspects of patient management. Clinicians, therefore, rely upon engrained treatment …

Approximately half of patients with heart failure have preserved ejection fraction. There is no
proven treatment that improves outcome. The pathophysiology of heart failure with …