Abstract Analysis of 78 Huntington's disease (HD) chromosomes with multi–allele markers
revealed 26 different haplotypes, suggesting a variety of independent HD mutations. The …

Wolf-Hirschhorn syndrome (WHS) is a well-known congenital malformation syndrome
caused by deletion of the short arm of chromosome 4 (4p-). In spite of more than 100 …

The Huntington's disease (HD) gene has been mapped in 4p16. 3 but has eluded
identification. We have used haplotype analysis of linkage disequilibrium to spotlight a small …

We determined the folding of chromosomes in interphase nuclei by measuring the distance
between points on the same chromosome. Over 25,000 measurements were made in G0/G1 …

Pulsed Field Gel Electrophoresis: A Practical Guide is the first laboratory manual to describe
the theory and practice of this technique. Based on the authors' experience developing …

The folding of chromatin in interphase cell nuclei was studied by fluorescent in situ
hybridization with pairs of unique DNA sequence probes. The sites of DNA sequences …

Wolf-Hirschhorn syndrome (WHS) is a multiple malformation syndrome characterised by
mental and developmental defects resulting from the absence of a segment of one …

The impact of predictive genetic testing for Huntington's disease (HD) was assessed in 68
persons at high (n= 17) or low risk (n= 51) for the disease at one to six years following …

We performed clinical, cytogenetic, and molecular analyses on 13 patients (8 females and 5
males, aged 6 months to 13 years) with Wolf-Hirschhorn syndrome due to de novo deletions …

The gene responsible for Huntington disease (HD), an autosomal dominant
neurodegenerative disorder, is located near the terminus of the short arm of chromosome 4 …