Transposable elements in human cancer: causes and consequences of deregulation
Transposable elements (TEs) comprise nearly half of the human genome and play an
essential role in the maintenance of genomic stability, chromosomal architecture, and …
essential role in the maintenance of genomic stability, chromosomal architecture, and …
Mechanisms and principles of homology search during recombination
J Renkawitz, CA Lademann, S Jentsch - Nature Reviews Molecular Cell …, 2014 - nature.com
Homologous recombination is crucial for genome stability and for genetic exchange.
Although our knowledge of the principle steps in recombination and its machinery is well …
Although our knowledge of the principle steps in recombination and its machinery is well …
[HTML][HTML] Contrasting evolutionary genome dynamics between domesticated and wild yeasts
Structural rearrangements have long been recognized as an important source of genetic
variation, with implications in phenotypic diversity and disease, yet their detailed …
variation, with implications in phenotypic diversity and disease, yet their detailed …
Homologous recombination and the formation of complex genomic rearrangements
The maintenance of genome integrity involves multiple independent DNA damage
avoidance and repair mechanisms. However, the origin and pathways of the focal …
avoidance and repair mechanisms. However, the origin and pathways of the focal …
Multi-invasions are recombination byproducts that induce chromosomal rearrangements
Inaccurate repair of broken chromosomes generates structural variants that can fuel
evolution and inflict pathology. We describe a novel rearrangement mechanism in which …
evolution and inflict pathology. We describe a novel rearrangement mechanism in which …
Chromosome rearrangements via template switching between diverged repeated sequences
RP Anand, O Tsaponina, PW Greenwell… - Genes & …, 2014 - genesdev.cshlp.org
Recent high-resolution genome analyses of cancer and other diseases have revealed the
occurrence of microhomology-mediated chromosome rearrangements and copy number …
occurrence of microhomology-mediated chromosome rearrangements and copy number …
Breaks in the 45S rDNA lead to recombination-mediated loss of repeats
DO Warmerdam, J van den Berg, RH Medema - Cell reports, 2016 - cell.com
Summary rDNA repeats constitute the most heavily transcribed region in the human
genome. Tumors frequently display elevated levels of recombination in rDNA, indicating that …
genome. Tumors frequently display elevated levels of recombination in rDNA, indicating that …
[HTML][HTML] Loss of heterozygosity drives adaptation in hybrid yeast
CSS Heil, CG DeSevo, DA Pai, CM Tucker… - … biology and evolution, 2017 - ncbi.nlm.nih.gov
Hybridization is often considered maladaptive, but sometimes hybrids can invade new
ecological niches and adapt to novel or stressful environments better than their parents. The …
ecological niches and adapt to novel or stressful environments better than their parents. The …
Loss of heterozygosity drives adaptation in hybrid yeast
CS Smukowski Heil, CG DeSevo, DA Pai… - Molecular biology …, 2017 - academic.oup.com
Hybridization is often considered maladaptive, but sometimes hybrids can invade new
ecological niches and adapt to novel or stressful environments better than their parents. The …
ecological niches and adapt to novel or stressful environments better than their parents. The …
[HTML][HTML] Recombination of repeat elements generates somatic complexity in human genomes
G Pascarella, CC Hon, K Hashimoto, A Busch… - Cell, 2022 - cell.com
Non-allelic recombination between homologous repetitive elements contributes to evolution
and human genetic disorders. Here, we combine short-and long-DNA read sequencing of …
and human genetic disorders. Here, we combine short-and long-DNA read sequencing of …