Toward the Development of a Circulating Free DNA-Based In Vitro Diagnostic Test for Infectious Diseases: a Review of Evidence for Tuberculosis
BL Fernández-Carballo, T Broger, R Wyss… - Journal of clinical …, 2019 - Am Soc Microbiol
The detection of circulating free DNA (cfDNA) has transformed the field of oncology and
prenatal diagnostics. Clinical application of cfDNA for disease diagnosis and monitoring …
prenatal diagnostics. Clinical application of cfDNA for disease diagnosis and monitoring …
Molecular diagnostics for human leptospirosis
JJ Waggoner, BA Pinsky - Current opinion in infectious diseases, 2016 - journals.lww.com
Molecular diagnostics have an established role for the diagnosis of leptospirosis and
provide an actionable diagnosis in the acute setting. The use of real-time reverse …
provide an actionable diagnosis in the acute setting. The use of real-time reverse …
Association of rodent-borne Leptospira spp. with urban environments in Malaysian Borneo
Although leptospirosis is traditionally considered a disease of rural, agricultural and flooded
environments, Leptospira spp. are found in a range of habitats and infect numerous host …
environments, Leptospira spp. are found in a range of habitats and infect numerous host …
Leptospirosis in Indonesia: diagnostic challenges associated with atypical clinical manifestations and limited laboratory capacity
MH Gasem, U Hadi, B Alisjahbana, E Tjitra… - BMC infectious …, 2020 - Springer
Background The burden of leptospirosis in Indonesia is poorly understood. Data from an
observational study conducted from 2013 to 2016 in seven cities across Indonesia was used …
observational study conducted from 2013 to 2016 in seven cities across Indonesia was used …
High Leptospira Diversity in Animals and Humans Complicates the Search for Common Reservoirs of Human Disease in Rural Ecuador
V Barragan, J Chiriboga, E Miller, S Olivas… - PLoS neglected …, 2016 - journals.plos.org
Background Leptospirosis is a zoonotic disease responsible for high morbidity around the
world, especially in tropical and low income countries. Rats are thought to be the main …
world, especially in tropical and low income countries. Rats are thought to be the main …
Genetic diversity of Leptospira strains circulating in humans and dogs in France in 2019-2021
M Garcia-Lopez, C Lorioux, A Soares… - Frontiers in Cellular …, 2023 - frontiersin.org
Leptospirosis is a bacterial zoonotic disease. Humans and dogs are susceptible hosts, with
similar clinical manifestations ranging from a febrile phase to multiple organ dysfunction …
similar clinical manifestations ranging from a febrile phase to multiple organ dysfunction …
Diagnosis of Human Leptospirosis in a Clinical Setting: Real-Time PCR High Resolution Melting Analysis for Detection of Leptospira at the Onset of Disease
LM Esteves, SM Bulhões, CC Branco, T Carreira… - Scientific reports, 2018 - nature.com
Currently, direct detection of Leptospira can be done in clinical laboratories by conventional
and by real-time PCR (qRT-PCR). We tested a biobank of paired samples of serum and …
and by real-time PCR (qRT-PCR). We tested a biobank of paired samples of serum and …
Efficacy of commercially available vaccines against canine leptospirosis: A systematic review and meta-analysis
SB Esteves, CM Santos, FF Salgado, AP Goncales… - Vaccine, 2022 - Elsevier
Background Leptospirosis is a worldwide distributed zoonosis that affects most mammal
species, including dogs and humans. Vaccination is the main strategy to control disease and …
species, including dogs and humans. Vaccination is the main strategy to control disease and …
Rapid, actionable diagnosis of urban epidemic leptospirosis using a pathogenic Leptospira lipL32-based real-time PCR assay
IN Riediger, RA Stoddard, GS Ribeiro… - PLoS neglected …, 2017 - journals.plos.org
Background With a conservatively estimated 1 million cases of leptospirosis worldwide and
a 5–10% fatality rate, the rapid diagnosis of leptospirosis leading to effective clinical and …
a 5–10% fatality rate, the rapid diagnosis of leptospirosis leading to effective clinical and …
Identification of Pathogenic Leptospira kirschneri Serogroup Grippotyphosa in Water Voles (Arvicola terrestris) from Ruminant Pastures in Puy-de-Dôme, Central …
E Harran, A Pinot, A Kodjo, Z Djelouadji, M Le Gudayer… - Pathogens, 2023 - mdpi.com
Rodents are the primary reservoirs for pathogenic Leptospira species, which cause
leptospirosis. Among the key potential carriers are water voles, whose population outbreaks …
leptospirosis. Among the key potential carriers are water voles, whose population outbreaks …