Cerebral cavernous malformations are acquired vascular anomalies that constitute a
common cause of central nervous system hemorrhage and stroke. The past 2 decades have …

Factor V Leiden is a genetic disorder characterized by a poor anticoagulant response to
activated Protein C and an increased risk for venous thromboembolism. Deep venous …

Background Hereditary and acquired thrombophilia are risk factors for venous
thromboembolism (VTE). Whether testing helps guide management decisions is …

See also Borissoff JI, ten Cate H. From neutrophil extracellular traps release to thrombosis:
an overshooting host‐defense mechanism? This issue, pp 1791–4. Summary Background …

Modern thrombophilia testing fails to identify any underlying prothrombotic tendency in a
significant number of patients presenting with objectively confirmed venous …

Coagulation involves the regulated sequence of proteolytic activation of a series of
zymogens to achieve appropriate and timely haemostasis in an injured vessel, in an …

Introduction: Fifty-three years after the first description of an inherited prothrombotic
condition (antithrombin deficiency), our knowledge on hereditary and acquired causes of …

Venous thromboembolism (VTE) is major health problem and is sometimes complicated by
lethal pulmonary embolism (PE). Disturbances of the coagulation and anticoagulation …

Objective To investigate the antidiabetic properties of aqueous extract of stem bark of Afzelia
africana (A. africana) and its beneficial effect on haematological parameters in …

Plasma protein C is a serine protease zymogen that is transformed into the active, trypsin-
like protease, activated protein C (APC), which can exert multiple activities. For its …