Convection-enhanced delivery (CED) is a promising technique that generates a pressure
gradient at the tip of an infusion catheter to deliver therapeutics directly through the …

Convection-enhanced delivery (CED) is a bulk flow–driven process. Its properties permit
direct, homogeneous, targeted perfusion of CNS regions with putative therapeutics while …

Object. Glial cell line-derived neurotrophic factor (GDNF) has demonstrated significant
antiparkinsonian actions in several animal models and in a recent pilot study in England in …

✓ Convection-enhanced delivery (CED) is the continuous injection under positive pressure
of a fluid containing a therapeutic agent. This technique was proposed and introduced by …

The brain is highly accessible for nutrients and oxygen, however delivery of drugs to
malignant brain tumors is a very challenging task. Convection-enhanced delivery (CED) has …

Pediatric high‐grade gliomas (pHGG) comprise a deadly, heterogenous category of
pediatric gliomas with a clear need for more effective treatment options. Advances in high …

Malignant gliomas are the most frequently occurring, devastating primary brain tumors, and
are coupled with a poor survival rate. Despite the fact that complete neurosurgical resection …

Objective To investigate the safety and tolerability of convection‐enhanced delivery of an
adeno‐associated virus, serotype‐2 vector carrying glial cell line‐derived neurotrophic …

Clinical trials involving direct infusion of neurotrophic therapies for Parkinson's disease (PD)
have suffered from poor coverage of the putamen. The planned use of a novel interventional …

Advances in the fields of molecular and translational research, oncology, and surgery have
emboldened the medical community to believe that intrinsic brain tumors may be treatable …