Single-molecule FRET (smFRET) has become a mainstream technique for studying
biomolecular structural dynamics. The rapid and wide adoption of smFRET experiments by …

This is a short communication based on recent high-impact publications related to how
various chemical materials and substrate modifications could be tuned for nano-and …

Vacuolar-type adenosine triphosphatases (V-ATPases),–are electrogenic rotary
mechanoenzymes structurally related to F-type ATP synthases,. They hydrolyse ATP to …

Single-molecule imaging technologies, especially those based on fluorescence, have been
developed to probe both the equilibrium and dynamic properties of biomolecules at the …

Glutamate is the major excitatory neurotransmitter in the vertebrate central nervous system.
Once released, it binds to specific membrane receptors and transporters activating a wide …

The conformational motions of enzymes are crucial for their catalytic activities, but these
fluctuations are usually spontaneous and unsynchronized and thus difficult to obtain from …

Transporting small molecules across cell membranes is an essential process in cell
physiology. Many structurally diverse, secondary active transporters harness …

Uncovering the structure and function of biomolecules is a fundamental goal in structural
biology. Membrane‐embedded transport proteins are ubiquitous in all kingdoms of life …

The Pyrococcus horikoshii amino acid transporter GltPh revealed, like other channels and
transporters, activity mode switching, previously termed wanderlust kinetics. Unfortunately …

Membrane transporters mediate cellular uptake of nutrients, signaling molecules, and drugs.
Their overall mechanisms are often well understood, but the structural features setting their …