Lyme disease (Lyme borreliosis) is a tick-borne, zoonosis of adults and children caused by
genospecies of the Borrelia burgdorferi sensu lato complex. The ailment, widespread …

All members of the Borrelia genus that have been examined harbour a linear chromosome
that is about 900 kbp in length, as well as a plethora of both linear and circular plasmids in …

Lyme disease is the most common tick-borne human illness in North America. In order to
understand the molecular pathogenesis, natural diversity, population structure and epizootic …

The complement system is an ancient arm of the innate immune system that plays important
roles in pathogen recognition and elimination. Upon activation by microbes, complement …

Maintenance of Borrelia burgdorferi within its enzootic cycle requires a complex regulatory
pathway involving the alternative σ factors RpoN and RpoS and two ancillary trans-acting …

Bacterial species can adapt to significant changes in their environment by mutation followed
by selection, a phenomenon known as “adaptive evolution.” With the development of …

Borrelia burgdorferi, the etiological agent of Lyme disease, exploits an array of strategies to
establish infection and to overcome host innate and adaptive immune responses. One key …

Background Bacteria from the genus Borrelia are known to harbor numerous linear and
circular plasmids. We report here a comparative analysis of the nucleotide sequences of 236 …

Lyme disease (LD), which is caused by genospecies of the Borrelia burgdorferi sensu lato
complex, is the most common vector-borne disease in the Northern hemisphere …

Abstract Background Bacteria of the Borrelia burgdorferi sensu lato (sl) complex can cause
Lyme borreliosis. Different B. burgdorferi sl genospecies vary in their host and vector …