Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. It is now well accepted that moderate …

The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …

Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the
second leading cause of cancer death worldwide. The modern concept of cancer biology …

Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of
human diseases including cancer. In this line, now it has become evident that ROS …

Piperlongumine, a white to beige biologically active alkaloid/amide phytochemical, has high
pharmacological relevance as an anticancer agent. Piperlongumine has several biological …

Simple Summary Autophagy is a physiological process characterized by the degradation of
the cell components through lysosomes due to stimuli/stress. In this study, we review the …

Natural products have long been an important source for discovery of new drugs to treat
human diseases. Piperlongumine (PL) is an amide alkaloid isolated from Piper longum …

Acute myeloid leukemia (AML) is a very heterogeneous group of disorders with large
differences in the percentage of immature blasts that presently are classified according to …

Abstract Copper transporter 1 (CTR1) plays an important role in increasing cisplatin intake.
Our previous studies showed that CTR1 expression was upregulated by (−) …

Acute myeloid leukemia (AML) remains the most lethal of leukemias and a small population
of cells called leukemic stem cells (LSCs) has been associated with disease relapses. Some …