The role of B cells in the pathogenesis of systemic sclerosis: an update

LI Sakkas, CG Katsiari, D Daoussis… - Rheumatology, 2023 - academic.oup.com
The pathogenesis of SSc is incompletely understood, but several lines of evidence suggest
that B cells are involved. Effector B (Beff) cells are hyperactivated and produce …

Lymphocyte depleting and modulating therapies for chronic lung allograft dysfunction

S Bos, P Pradère, H Beeckmans, A Zajacova… - Pharmacological …, 2023 - Elsevier
Chronic lung rejection, also called chronic lung allograft dysfunction (CLAD), remains the
major hurdle limiting long-term survival after lung transplantation, and limited therapeutic …

[HTML][HTML] Ibrutinib in steroid-refractory chronic graft-versus-host disease, a single-center experience

KK Chin, HT Kim, EA Inyang, V Ho, J Koreth… - … and Cellular Therapy, 2021 - Elsevier
Chronic graft-versus-host disease (cGVHD) is a leading cause of late morbidity and mortality
after allogenic hematopoietic stem cell transplantation. Corticosteroid-based therapies are a …

An open‐label study of belumosudil, a selective ROCK2 inhibitor, as second or subsequent line of therapy for steroid‐dependent/steroid‐resistant chronic GVHD

Y Inamoto, K Kato, T Kawakita, Y Onishi… - American Journal of …, 2024 - Wiley Online Library
Belumosudil mesylate is a selective Rho‐associated coiled‐coil kinase 2 inhibitor with
immunomodulatory and antifibrosis effects. This multicenter, open‐label, single‐arm study …

Novel Pharmacological Treatment Options of Steroid‐Refractory Graft‐versus‐Host Disease

I Kovalenko, T Saleem, M Shah… - Advances in …, 2023 - Wiley Online Library
Background. Graft‐versus‐host disease (GVHD) is a potentially fatal complication of
allogeneic hematopoietic stem cell transplant. The mainstay of treatment is corticosteroids …

ERS/EBMT clinical practice guidelines on treatment of pulmonary chronic graft-versus-host disease in adults

S Bos, J Murray, M Marchetti, GS Cheng… - European …, 2024 - Eur Respiratory Soc
Chronic graft-versus-host disease (cGvHD) is a common complication after allogeneic
haematopoietic stem cell transplantation, characterised by a broad disease spectrum that …

[HTML][HTML] Oral Chronic Graft-Versus-Host Disease: Pathogenesis, Diagnosis, Current Treatment, and Emerging Therapies

JT Nguyen, M Jessri, AC Costa-da-Silva… - International Journal of …, 2024 - mdpi.com
Chronic graft-versus-host disease (cGvHD) is a multisystem disorder that occurs in
recipients of allogeneic hematopoietic (alloHCT) stem cell transplants and is characterized …

Effectiveness of Ibrutinib in the Management of Chronic GVHD

MA Erkurt, A Sarici, A Sahin, I Berber… - … and Apheresis Science, 2024 - Elsevier
Objectives Chronic graft-versus-host disease (cGVHD) represents a significant adverse
event that may ensue following allogeneic hematopoietic stem cell transplantation (Allo …

Clinical features of non-infectious pulmonary complications after donor lymphocyte infusion in post-transplant patients: The Nagasaki Transplant Group Experience

M Fujioka, H Itonaga, T Furumoto, C Sakaki… - Transplant …, 2022 - Elsevier
Donor lymphocyte infusion (DLI) is a therapeutic modality for relapsed hematological
malignancies after allogeneic hematopoietic stem cell transplantation. We retrospectively …

[HTML][HTML] Efficacy and Safety of Ibrutinib for Chronic Graft-Versus-Host Disease: A Systematic Review

D Santosa, D Rizky, K Tandarto, I Kartiyani… - Asian Pacific Journal …, 2023 - ncbi.nlm.nih.gov
Method: We incorporated search engines from PubMed, Embase, Cochrane Library,
Scopus, Web of Science, and ClinicalTrials. gov. The study was performed following the …