Ferroptosis: Promising approach for cancer and cancer immunotherapy

S Zheng, XY Guan - Cancer Letters, 2023 - Elsevier
Ferroptosis is the cell death induced by ferrous ions and lipid peroxidation accumulation in
tumor cells. Targeting ferroptosis, which is regulated by various metabolic and immune …

Role of lipoproteins in the pathophysiology of breast cancer

SL Pandrangi, P Chittineedi, R Chikati, JAN Mosquera… - Membranes, 2022 - mdpi.com
Breast cancer is one of the most common malignancies in women and the leading cause of
cancer mortality. Hypercholesterolemia and obesity are potential risk factors for the …

Depletion of Labile Iron Induces Replication Stress and Enhances Responses to Chemoradiation in Non-Small-Cell Lung Cancer

K Bayanbold, M Singhania, MA Fath, CC Searby… - Antioxidants, 2023 - mdpi.com
The intracellular redox-active labile iron pool (LIP) is weakly chelated and available for
integration into the iron metalloproteins that are involved in diverse cellular processes …

Ferroptosis: new insight into the mechanisms of diabetic nephropathy and retinopathy

L Li, Y Dai, D Ke, J Liu, P Chen, D Wei… - Frontiers in …, 2023 - frontiersin.org
Diabetic nephropathy (DN) and diabetic retinopathy (DR) are the most serious and common
diabetes-associated complications. DN and DR are all highly prevalent and dangerous …

Design, Synthesis and Cytotoxicity Screening of New Thiazole Derivatives as Potential Anticancer Agents through VEGFR-2 Inhibition

T Al-Warhi, M Abualnaja, OA Abu Ali, NM Alyamani… - Symmetry, 2022 - mdpi.com
Z-configurated isomers are kinetically preferred molecules. Compounds with Z-configuration
are contained in many natural products, biologically active compounds and as synthons for …

Polysaccharide of Atractylodes macrocephala Koidz Alleviates Cyclophosphamide-Induced Thymus Ferroptosis in Gosling

X Zhou, N Cao, D Xu, Y Tian, X Shen, D Jiang… - Animals, 2022 - mdpi.com
Simple Summary During the brooding stage, the goslings are susceptible to various
stresses, damaging the thymus and decreasing immune function. Ferroptosis is cell death …

Ferroptosis contributes to cyclophosphamide-induced hemorrhagic cystitis

Z Mao, K Zhong, X Liu, X Zeng - Chemico-Biological Interactions, 2023 - Elsevier
Cyclophosphamide (CYP) is extensively used in tumor therapy, but its clinical application is
limited by its toxic effects on the bladder. Since CYP-induced cystitis is believed to be …

Ferroptosis: A novel therapeutic strategy and mechanism of action in glioma

G Zhang, Y Fang, X Li, Z Zhang - Frontiers in oncology, 2022 - frontiersin.org
Glioma is the most common malignant tumor of the central nervous system and resistance is
easily developed to chemotherapy drugs during the treatment process, resulting in high …

Polyherbal formulation conjugated to gold nanoparticles induced ferroptosis in drug-resistant breast cancer stem cells through ferritin degradation

P Chittineedi, A Mohammed… - Frontiers in …, 2023 - frontiersin.org
Aim: Due to their minimal side effects, the anti-cancer properties of the polyherbal
formulation are being investigated. However, due to their low absorption potential, the …

Aqueous Nyctanthes arbortristis and doxorubicin conjugated gold nanoparticles synergistically induced mTOR-dependent autophagy-mediated ferritinophagy in …

P Chittineedi, SL Pandrangi… - Frontiers in …, 2023 - frontiersin.org
Aim: Nyctanthes arbortristis Linn is a potential anti-diabetic drug that reduces glucose levels
by delaying carbohydrate digestion. The tumor microenvironment is characterized by …