Fingerprinting and profiling in metabolomics of biosamples

V Ghini, G Meoni, A Vignoli, F Di Cesare… - Progress in Nuclear …, 2023 - Elsevier
This review focuses on metabolomics from an NMR point of view. It attempts to cover the
broad scope of metabolomics and describes the NMR experiments that are most suitable for …

Metabolomics as a powerful tool for diagnostic, pronostic and drug intervention analysis in COVID-19

C Bruzzone, R Conde, N Embade, JM Mato… - Frontiers in Molecular …, 2023 - frontiersin.org
COVID-19 currently represents one of the major health challenges worldwide. Albeit its
infectious character, with onset affectation mainly at the respiratory track, it is clear that the …

A patient-centric modeling framework captures recovery from SARS-CoV-2 infection

H Ruffieux, AL Hanson, S Lodge, NG Lawler… - Nature …, 2023 - nature.com
The biology driving individual patient responses to severe acute respiratory syndrome
coronavirus 2 infection remains ill understood. Here, we developed a patient-centric …

Profiling metabolites and lipoproteins in COMETA, an Italian cohort of COVID-19 patients

V Ghini, G Meoni, L Pelagatti, T Celli… - PLoS …, 2022 - journals.plos.org
Metabolomics and lipidomics have been used in several studies to define the biochemical
alterations induced by COVID-19 in comparison with healthy controls. Those studies …

Metabolomics analysis identifies glutamic acid and cystine imbalances in COVID-19 patients without comorbid conditions. Implications on redox homeostasis and …

JC Páez-Franco, JL Maravillas-Montero… - PLoS …, 2022 - journals.plos.org
It is well known that the presence of comorbidities and age-related health issues may hide
biochemical and metabolic features triggered by SARS-CoV-2 infection and other diseases …

1H qNMR-Based Metabolomics Discrimination of Covid-19 Severity

BSB Correia, VG Ferreira, PMFD Piagge… - Journal of Proteome …, 2022 - ACS Publications
The coronavirus disease 2019 (Covid-19), which caused respiratory problems in many
patients worldwide, led to more than 5 million deaths by the end of 2021. Experienced …

COVID-19: A complex disease with a unique metabolic signature

V Ghini, W Vieri, T Celli, V Pecchioli, N Boccia… - PLoS …, 2023 - journals.plos.org
Plasma of COVID-19 patients contains a strong metabolomic/lipoproteomic signature,
revealed by the NMR analysis of a cohort of> 500 patients sampled during various waves of …

Saliva metabolomic profile of COVID-19 patients associates with disease severity

N Saheb Sharif-Askari, NC Soares, HA Mohamed… - Metabolomics, 2022 - Springer
Abstract Introduction Coronavirus disease 2019 (COVID-19) is strongly linked to
dysregulation of various molecular, cellular, and physiological processes that change …

Integrative plasma metabolic and lipidomic modelling of SARS-CoV-2 infection in relation to clinical severity and early mortality prediction

S Lodge, NG Lawler, N Gray, R Masuda… - International Journal of …, 2023 - mdpi.com
An integrative multi-modal metabolic phenotyping model was developed to assess the
systemic plasma sequelae of SARS-CoV-2 (rRT-PCR positive) induced COVID-19 disease …

Plasma phospholipids: a promising simple biochemical parameter to evaluate COVID-19 infection severity

MA Hussein, NEM Ismail… - … and Biology Insights, 2021 - journals.sagepub.com
Background: Coronavirus-19 (COVID-19) pandemic is a worldwide public health problem
that has been known in China since December 25, 2019. Phospholipids are structural …