The large conductance calcium-and voltage-activated K+ channel (KCa1. 1, BK, MaxiK) is
ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular …

Contraction and relaxation of the detrusor smooth muscle (DSM), which makes up the wall of
the urinary bladder, facilitates the storage and voiding of urine. Several families of K+ …

The physiological functions of the urinary bladder are to store and periodically expel urine.
These tasks are facilitated by the contraction and relaxation of the urinary bladder smooth …

Large conductance, Ca2+-activated K+ (BK) channels represent an important pathway for
the outward flux of K+ ions from the intracellular compartment in response to membrane …

The large-conductance voltage-and Ca2+-activated K+ (BK) channel is expressed in many
smooth muscle types, but its role in human detrusor smooth muscle (DSM) is unclear. With a …

Urinary bladder smooth muscle (UBSM), also known as detrusor smooth muscle, forms the
bladder wall and ultimately determines the two main attributes of the organ: urine storage …

As current clinical approaches for lower urinary tract (LUT) dysfunction such as
pharmacological and electrical stimulation treatments lack target specificity, thus resulting in …

Patients suffering from a variety of neurological diseases such as spinal cord injury,
Parkinson's disease, and multiple sclerosis often develop neurogenic detrusor overactivity …

Overactive bladder syndrome is frequently associated with increased detrusor smooth
muscle (DSM) contractility. We tested the hypothesis that pharmacological activation of the …

Background and Purpose BK channels play important roles in various physiological and
pathophysiological processes and thus have been the target of several drug development …