In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …

Amyloid-beta (Aß) and hyperphosphorylated tau are hallmark lesions of Alzheimer's disease
(AD). However, the loss of synapses and dysfunctions of neurotransmission are more …

In spike-timing-dependent plasticity (STDP), the order and precise temporal interval
between presynaptic and postsynaptic spikes determine the sign and magnitude of long …

Axons are generally considered as reliable transmission cables in which stable propagation
occurs once an action potential is generated. Axon dysfunction occupies a central position in …

Synaptic plasticity is the capacity of a preexisting connection between two neurons to
change in strength as a function of neural activity. Because synaptic plasticity is the major …

Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …

Endocannabinoid mediated spike timing–dependent depression (t-LTD) is crucially involved
in the development of the sensory neocortex. t-LTD at excitatory synapses in the developing …

N-Methyl-d-aspartate receptor (NMDAR)-dependent synaptic plasticity is a strong candidate
to mediate learning and memory processes that require the hippocampus. This plasticity is …

Synaptic plasticity confers environmental adaptability through modification of the
connectivity between neurons and neuronal circuits. This is achieved through changes to …

Endocannabinoids (eCBs) are key activity-dependent signals regulating synaptic
transmission throughout the central nervous system. Accordingly, eCBs are involved in …