Cancer is one of the most common causes of death globally. Despite extensive research
and considerable advances in cancer therapy, the fundamentals of the disease remain …

Due to its poor prognosis and the late stage at which it is typically diagnosed, early detection
of pancreatic cancer is a pressing clinical problem. Advances in genomic analysis of human …

Cancer is a complex disease resulting from abnormal cell growth that is induced by a
number of genetic and environmental factors. The tumor microenvironment (TME), which …

Background & Aims Intraductal oncocytic papillary neoplasms (IOPNs) of the pancreas and
bile duct contain epithelial cells with numerous, large mitochondria and are cystic precursors …

The DNAJB1-PRKACA fusion transcript is the oncogenic driver in fibrolamellar
hepatocellular carcinoma, a lethal disease lacking specific therapies. This study reports on …

Many of the fundamental concepts of signal transduction and kinase activity are attributed to
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …

Abstract Background/Objectives: Intraductal papillary mucinous neoplasms (IPMNs) are a
cystic precursor to pancreatic cancer. IPMNs deemed clinically to be at high-risk for …

Fibrolamellar carcinoma (FLC), a rare, lethal hepatic cancer, occurs primarily in adolescents
and young adults. Unlike hepatocellular carcinoma, FLC has no known association with …

Fibrolamellar carcinoma (FLC) is a rare malignant entity arising from the liver and primarily
affecting patients in late adolescence and young adulthood. FLC tumors are characterized …

The fight against rare cancers faces myriad challenges, including missed or wrong
diagnoses, lack of information and diagnostic tools, too few samples and too little funding …