The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …

Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

It has been over 20 years since JUN amino-terminal kinases (JNKs) were identified as
protein kinases that are strongly activated by cellular stress and that have a key role in …

Treadmill exercise and mesenchymal stem cell transplantation are both practical and
effective methods for the treatment of cerebral ischemia. However, whether there is a …

The c-Jun NH2-terminal protein kinase (JNK) is a Janus-faced kinase, which, in the nervous
system, plays important roles in a broad range of physiological and pathological processes …

Cell-based therapies are emerging as new promising treatments in stroke. However, their
functional mechanism and therapeutic potential during early infarct maturation has so far …

Although many pathogenic copy number variations (CNVs) are associated with
neuropsychiatric diseases, few of them have been functionally characterised. Here we report …

A fundamental feature of both early nervous system development and axon regeneration is
the guidance of axonal projections to their targets in order to assemble neural circuits that …

Precise modulation of the cytoskeleton is involved in a variety of cellular processes including
cell division, migration, polarity, and adhesion. In developing post-mitotic neurons …

In mouse embryonic stem cells (mESCs), chemical blockade of Gsk3α/β and Mek1/2 (2i)
instructs a self-renewing ground state whose endogenous inducers are unknown. Here we …