Imaging and biophysical modelling of thrombogenic mechanisms in atrial fibrillation and stroke

A Qureshi, GYH Lip, DA Nordsletten… - Frontiers in …, 2023 - frontiersin.org
Atrial fibrillation (AF) underlies almost one third of all ischaemic strokes, with the left atrial
appendage (LAA) identified as the primary thromboembolic source. Current stroke risk …

Device-Related Thrombus After Left Atrial Appendage Occlusion: Clinical Impact, Predictors, Classification, and Management

M Alkhouli, H Alarouri, A Kramer, K Korsholm… - Cardiovascular …, 2023 - jacc.org
Despite the unprecedented advances in the left atrial appendage occlusion field, device-
related thrombus (DRT) remains an unresolved issue with the therapy. This paper aims to …

Joint analysis of morphological parameters and in silico haemodynamics of the left atrial appendage for thrombogenic risk assessment

MI Pons, J Mill, A Fernandez-Quilez… - Journal of …, 2022 - Wiley Online Library
Background. Atrial fibrillation (AF) is considered the most common human arrhythmia. In
nonvalvular AF, around 99% of thrombi are formed in the left atrial appendage (LAA) …

[HTML][HTML] Device-related thrombus following left atrial appendage occlusion

TJ Simard, B Hibbert, MA Alkhouli… - …, 2022 - eurointervention.pcronline.com
Thrombus formation on intracardiac devices remains a subject of importance, with rates in
the 2-5% range. Device-related thrombus (DRT) following left atrial appendage occlusion is …

Impact of occluder device configurations in in-silico left atrial hemodynamics for the analysis of device-related thrombus

C Albors, J Mill, AL Olivares, X Iriart… - PLOS Computational …, 2024 - journals.plos.org
Left atrial appendage occlusion devices (LAAO) are a feasible alternative for non-valvular
atrial fibrillation (AF) patients at high risk of thromboembolic stroke and contraindication to …

A comprehensive stroke risk assessment by combining atrial computational fluid dynamics simulations and functional patient data

A Zingaro, Z Ahmad, E Kholmovski, K Sakata… - Scientific reports, 2024 - nature.com
Stroke, a major global health concern often rooted in cardiac dynamics, demands precise
risk evaluation for targeted intervention. Current risk models, like the CHA 2 DS 2-VASc …

Slow blood-flow in the left atrial appendage is associated with stroke in atrial fibrillation patients

N Paliwal, HC Park, Y Mao, SJ Hong, Y Lee… - Heliyon, 2024 - cell.com
Background Atrial fibrillation (AF) patients are at high risk of stroke with∼ 90% clots
originating from the left atrial appendage (LAA). Clinical understanding of blood-flow based …

Impact of left atrial appendage occlusion device position on potential determinants of device-related thrombus: a patient-specific in silico study

Z Zhong, Y Gao, S Kovács, V Vij, D Nelles… - Clinical Research in …, 2024 - Springer
Background Device-related thrombus (DRT) after left atrial appendage occlusion (LAAO) is
potentially linked to adverse events. Although clinical reports suggest an effect of the device …

Preliminary findings on left atrial appendage occlusion simulations applying different endocardial devices

N D'Alessandro, M Falanga, A Masci… - Frontiers in …, 2023 - frontiersin.org
Atrial fibrillation (AF) is one of the most investigated arrhythmias since it is associated with a
five-fold increase in the risk of strokes. Left atrium dilation and unbalanced and irregular …

A digital twin approach for stroke risk assessment in Atrial Fibrillation Patients

M Falanga, C Cortesi, A Chiaravalloti, A Dal Monte… - Heliyon, 2024 - cell.com
Atrial fibrillation (AF) is associated with a fivefold increased risk of cerebrovascular events,
contributing to 15–18% of all strokes. Stroke prevention in clinical practice is typically guided …