International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …
therapeutics and various drugs in development. Their diversity of structure and function …
Analyzing dendritic spine pathology in Alzheimer's disease: problems and opportunities
Synaptic failure is an immediate cause of cognitive decline and memory dysfunction in
Alzheimer's disease. Dendritic spines are specialized structures on neuronal processes, on …
Alzheimer's disease. Dendritic spines are specialized structures on neuronal processes, on …
[HTML][HTML] Recent advances in the neurobiology and neuropharmacology of Alzheimer's disease
K Kumar, A Kumar, RM Keegan… - Biomedicine & …, 2018 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by
progressive deterioration of cognitive functions. The pathological hallmarks are extracellular …
progressive deterioration of cognitive functions. The pathological hallmarks are extracellular …
Cognitive and affective Theory of Mind in neurodegenerative diseases: neuropsychological, neuroanatomical and neurochemical levels
The paper reviews of all of the current evidence on Theory of Mind (ToM) abilities in patients
with neurodegenerative diseases. ToM refers to the abilities to attribute mental states to …
with neurodegenerative diseases. ToM refers to the abilities to attribute mental states to …
Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care
Extensive neuropathological studies have established a compelling link between
abnormalities in structure and function of subcortical monoaminergic (MA-ergic) systems …
abnormalities in structure and function of subcortical monoaminergic (MA-ergic) systems …
Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with …
Background Both serotonergic signalling disruption and systemic inflammation have been
associated with the pathogenesis of Alzheimer's disease (AD). The common denominator …
associated with the pathogenesis of Alzheimer's disease (AD). The common denominator …
The role of serotonin in memory: interactions with neurotransmitters and downstream signaling
Abstract Serotonin, or 5-hydroxytryptamine (5-HT), is found to be involved in many
physiological or pathophysiological processes including cognitive function. Seven distinct …
physiological or pathophysiological processes including cognitive function. Seven distinct …
Serotonin degeneration and amyloid-β deposition in mild cognitive impairment: relationship to cognitive deficits
GS Smith, H Kuwabara, H Yan… - Journal of …, 2023 - journals.sagepub.com
Background: Neuropathological and neuroimaging studies have demonstrated
degeneration of the serotonin system in Alzheimer's disease (AD). Neuroimaging studies …
degeneration of the serotonin system in Alzheimer's disease (AD). Neuroimaging studies …
Incidence of and risk factors for Alzheimer's disease and mild cognitive impairment in Korean elderly
Abstract Background/Aims: Knowledge of incidence rates and risk factors is essential for the
development of strategies to treat patients with Alzheimer's disease (AD) and mild cognitive …
development of strategies to treat patients with Alzheimer's disease (AD) and mild cognitive …
Serotonin and molecular neuroimaging in humans using PET
A Saulin, M Savli, R Lanzenberger - Amino acids, 2012 - Springer
The serotonergic system is one of the most important modulatory neurotransmitter systems
in the human brain. It plays a central role in major physiological processes and is implicated …
in the human brain. It plays a central role in major physiological processes and is implicated …