Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …

Parkinson's disease is the second most common neurodegenerative disease and its
prevalence has been projected to double over the next 30 years. An accurate diagnosis of …

Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …

The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …

Importance Urate elevation, despite associations with crystallopathic, cardiovascular, and
metabolic disorders, has been pursued as a potential disease-modifying strategy for …

The clinical definition of neurodegenerative diseases is based on symptoms that reflect
terminal damage of specific brain regions. This is misleading as it tells little about the initial …

Parkinson's disease (PD) is a common motor disorder that has become increasingly
prevalent in the ageing population. Recent works have suggested that circadian rhythms …

Abstract Alpha-synuclein (α-syn) has been suggested to have many functions including,
vesicle transport in neurons, transcriptional regulator, modulator of immune cell maturation …

Parkinson's disease has a large heritable component and genome-wide association studies
have identified over 90 variants with disease-associated common variants, providing deeper …

Parkinson's disease (PD) is a progressive neurodegenerative disease that impairs
movement as well as causing multiple other symptoms such as autonomic dysfunction, rapid …