Life exists in three dimensions, but until the turn of the century most electron microscopy
methods provided only 2D image data. Recently, electron microscopy techniques capable of …

Considerable progress has been made in our knowledge of the morphological and
functional varieties of anchoring junctions. Cell-cell adhesion contacts consist of discrete …

The cavin proteins are essential for caveola biogenesis and function. Here, we identify a role
for the muscle-specific component, Cavin4, in skeletal muscle T-tubule development by …

Unambiguous targeting of cellular structures for in situ cryo-electron microscopy in the
heterogeneous, dense and compacted environment of the cytoplasm remains challenging …

High-throughput anatomic data can stimulate and constrain new hypotheses about how
neural circuits change in response to experience. Here, we use fluorescence-based …

Imaging is one of the key technologies underpinning discoveries in biomedical research.
Each imaging technique however usually only provides a specific type of information. For …

Post-embedding correlative light and electron microscopy (CLEM) has the advantage of
high-precision registration and enables light and electron microscopy imaging of the same …

Peroxidase is a heme-containing enzyme that reduces hydrogen peroxide to water by
extracting electron (s) from aromatic compounds via a sequential turnover reaction. This …

Microscopy has served as a fundamental tool for insight and discovery in plant-microbe
interactions for centuries. From classical light and electron microscopy to corresponding …

Ultrastructural analysis of discrete neurobiological structures by volume scanning electron
microscopy (SEM) often constitutes a “needle-in-the-haystack” problem and therefore relies …