Recent strategies for the treatment of cancer, other than just tumor cell killing have been
under intensive development, such as anti-angiogenic therapeutic approach. Angiogenesis …

Angiogenesis is known as one of the hallmarks in cancer which could play a key role in
providing oxygen and nutrients for tumor cells. It has been shown that tumor cannot grow …

Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate
and ammonia to glutamine. It is expressed by endothelial cells, but surprisingly shows …

Cdc42 plays important roles in cytoskeleton organization, cell cycle progression, signal
transduction, and vesicle trafficking. Overactive Cdc42 has been implicated in the pathology …

Current antiangiogenic therapy is limited by its cytostatic nature and systemic side effects. To
address these limitations, we have unveiled the role of RhoJ, an endothelial-enriched Rho …

The process of angiogenesis is quite well-known nowadays. Some medicines and extracts
affecting this process are already used routinely in supporting the conventional treatment of …

Glioblastoma (GBM) is a highly vascularized malignant tumor that depends on new blood
vessel formation. Small molecules targeting the angiogenic process may be an effective anti …

The vascular system is a hierarchically organized network of blood vessels that play crucial
roles in embryogenesis, homeostasis and disease. Blood vessels are built by endothelial …

Actin, one of the most abundant intracellular proteins in mammalian cells, is a critical
regulator of cell shape and polarity, migration, cell division, and transcriptional response …

Both Dictyostelium amoebae and mammalian cells are endowed with an elaborate actin
cytoskeleton that enables them to perform a multitude of tasks essential for survival …