The endocannabinoid system (ECS) is a widespread neuromodulatory network involved in
the developing central nervous system as well as playing a major role in tuning many …

Recent years have been transformational in regard to the perception of the health risks and
benefits of cannabis with increased acceptance of use. This has unintended …

Dr. Metz was supported by the Eunice Kennedy Shriver National Institute of Child Health
and Human Development under award number 5K12HD001271-18. The content is solely …

A wealth of research over the past 2 decades has expanded our understanding of the impact
of early‐life adversity on physiological function and, consequently, health and wellbeing in …

Among the many signalling lipids, endocannabinoids are increasingly recognized for their
important roles in neuronal and glial development. Recent experimental evidence suggests …

CB 1 cannabinoid receptors appear to mediate most, if not all of the psychoactive effects of
delta-9-tetrahydrocannabinol and related compounds. This G protein-coupled receptor has …

Intrapartum-related events are the third leading cause of childhood mortality worldwide and
result in one million neurodisabled survivors each year. Infants exposed to a perinatal insult …

Background The past two decades have seen an increase in cannabis use due to both
regulatory changes and an interest in potential therapeutic effects of the substance, yet …

The roles of endocannabinoid signaling during central nervous system development are
unknown. We report that CB1 cannabinoid receptors (CB1Rs) are enriched in the axonal …

In the postnatal brain, endocannabinoids acting as retrograde messengers regulate the
function of many synapses. By contrast, the understanding of endocannabinoid functions …