The AAA+ superfamily: a review of the structural and mechanistic principles of these molecular machines

YA Khan, KI White, AT Brunger - Critical reviews in biochemistry …, 2022 - Taylor & Francis
ATPases associated with diverse cellular activities (AAA+ proteins) are a superfamily of
proteins found throughout all domains of life. The hallmark of this family is a conserved …

The molecular principles governing the activity and functional diversity of AAA+ proteins

C Puchades, CR Sandate, GC Lander - Nature Reviews Molecular Cell …, 2020 - nature.com
ATPases associated with diverse cellular activities (AAA+ proteins) are macromolecular
machines that convert the chemical energy contained in ATP molecules into powerful …

PEX5 translocation into and out of peroxisomes drives matrix protein import

ML Skowyra, TA Rapoport - Molecular cell, 2022 - cell.com
Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal enzymes are imported from the cytosol by the receptor PEX5, which …

Protein import into peroxisomes occurs through a nuclear pore–like phase

Y Gao, ML Skowyra, P Feng, TA Rapoport - Science, 2022 - science.org
Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal proteins are imported from the cytosol in a folded state by the soluble …

A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel

P Feng, X Wu, SK Erramilli, JA Paulo, P Knejski… - Nature, 2022 - nature.com
Peroxisomes are ubiquitous organelles that house various metabolic reactions and are
essential for human health,,–. Luminal peroxisomal proteins are imported from the cytosol by …

Protocols for molecular modeling with Rosetta3 and RosettaScripts

BJ Bender, A Cisneros III, AM Duran, JA Finn, D Fu… - Biochemistry, 2016 - ACS Publications
Previously, we published an article providing an overview of the Rosetta suite of
biomacromolecular modeling software and a series of step-by-step tutorials [Kaufmann, KW …

The peroxisome: an update on mysteries 2.0

M Islinger, A Voelkl, HD Fahimi, M Schrader - Histochemistry and cell …, 2018 - Springer
Peroxisomes are key metabolic organelles, which contribute to cellular lipid metabolism, eg
the β-oxidation of fatty acids and the synthesis of myelin sheath lipids, as well as cellular …

Peroxisome function, biogenesis, and dynamics in plants

YT Kao, KL Gonzalez, B Bartel - Plant Physiology, 2018 - academic.oup.com
Peroxisome Function, Biogenesis, and Dynamics in Plants | Plant Physiology | Oxford
Academic Skip to Main Content Advertisement Oxford Academic Journals Books Search Menu …

Comparative genomics of peroxisome biogenesis proteins: making sense of the PEX proteins

RLM Jansen, C Santana-Molina… - Frontiers in cell and …, 2021 - frontiersin.org
PEX genes encode proteins involved in peroxisome biogenesis and proliferation. Using a
comparative genomics approach, we clarify the evolutionary relationships between the 37 …

Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1–Npl4

NO Bodnar, KH Kim, Z Ji, TE Wales, V Svetlov… - Nature structural & …, 2018 - nature.com
Many polyubiquitinated proteins are extracted from membranes or complexes by the
conserved ATPase Cdc48 (in yeast; p97 or VCP in mammals) before proteasomal …