Heritable variation in gene expression is common within and between species. This
variation arises from mutations that alter the form or function of molecular gene regulatory …

We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …

Abstract N 6-methyladenosine (m6A) plays important roles in regulating messenger RNA
processing. Despite rapid progress in this field, little is known about the genetic …

Regulatory variants are often context specific, modulating gene expression in a subset of
possible cellular states. Although these genetic effects can play important roles in disease …

Genome-wide association studies (GWASs) have enabled the discovery of common genetic
variation contributing to normal and pathological traits and clinical drug responses, but …

Background Degradation rate is a fundamental aspect of mRNA metabolism, and the factors
governing it remain poorly characterized. Understanding the genetic and biochemical …

Noncoding variants play a central role in the genetics of complex traits, but we still lack a full
understanding of the molecular pathways through which they act. We quantified the …

Identifying pairwise RNA-RNA interactions is key to understanding how RNAs fold and
interact with other RNAs inside the cell. We present a high-throughput approach …

Abstract Systems genetics is an approach to understand the flow of biological information
that underlies complex traits. It uses a range of experimental and statistical methods to …

The phenotypic consequences of expression quantitative trait loci (eQTLs) are presumably
due to their effects on protein expression levels. Yet the impact of genetic variation, including …