Therapeutics of 5-HT3 receptor antagonists: current uses and future directions
TK Machu - Pharmacology & therapeutics, 2011 - Elsevier
The 5-Hydroxytryptamine3 (5-HT3) receptor is a member of the cys-loop family of ligand
gated ion channels, of which the nicotinic acetylcholine receptor is the prototype. All other 5 …
gated ion channels, of which the nicotinic acetylcholine receptor is the prototype. All other 5 …
Structure, function and physiology of 5-hydroxytryptamine receptors subtype 3
E Gibbs, S Chakrapani - … Protein Complexes III: Structure and Function, 2021 - Springer
hydroxytryptamine receptor subtype 3 (5-HT 3 R) is a pentameric ligand-gated ion channel
(pLGIC) involved in neuronal signaling. It is best known for its prominent role in gut-CNS …
(pLGIC) involved in neuronal signaling. It is best known for its prominent role in gut-CNS …
A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and d-Tubocurarine by Different Cys-Loop Receptors
Cys-loop receptors (CLR) are pentameric ligand-gated ion channels that mediate fast
excitatory or inhibitory transmission in the nervous system. Strychnine and d-tubocurarine (d …
excitatory or inhibitory transmission in the nervous system. Strychnine and d-tubocurarine (d …
Phylogenetic analyses of 5-hydroxytryptamine 3 (5-HT3) receptors in Metazoa
The 5-hydroxytrptamine 3 (5-HT3) receptor is a member of the'Cys-loop'family and the only
pentameric ligand gated ion channel among the serotonin receptors. 5-HT3 receptors play …
pentameric ligand gated ion channel among the serotonin receptors. 5-HT3 receptors play …
Discriminating between 5‐HT3A and 5‐HT3AB receptors
AJ Thompson, SCR Lummis - British journal of pharmacology, 2013 - Wiley Online Library
The 5‐HT3B subunit was first cloned in 1999, and co‐expression with the 5‐HT3A subunit
results in heteromeric 5‐HT3AB receptors that are functionally distinct from homomeric 5 …
results in heteromeric 5‐HT3AB receptors that are functionally distinct from homomeric 5 …
Delineation of the unbinding pathway of α-conotoxin ImI from the α7 nicotinic acetylcholine receptor
α-Conotoxins potently and specifically inhibit isoforms of nicotinic acetylcholine receptors
(nAChRs) and are used as molecular probes and as drugs or drug leads. Interactions …
(nAChRs) and are used as molecular probes and as drugs or drug leads. Interactions …
Mutant cycle analysis identifies a ligand interaction site in an odorant receptor of the malaria vector Anopheles gambiae
S Rahman, CW Luetje - Journal of Biological Chemistry, 2017 - ASBMB
Lack of information about the structure of insect odorant receptors (ORs) hinders the
development of more effective repellants to control disease-transmitting insects …
development of more effective repellants to control disease-transmitting insects …
Mapping the Orthosteric Binding Site of the Human 5-HT3 Receptor Using Photo-cross-linking Antagonists
T Jack, M Leuenberger, MD Ruepp… - ACS chemical …, 2018 - ACS Publications
The serotonin-gated 5-HT3 receptor is a ligand-gated ion channel. Its location at the
synapse in the central and peripheral nervous system has rendered it a prime …
synapse in the central and peripheral nervous system has rendered it a prime …
[图书][B] Chemical modification of biological polymers
RL Lundblad - 2011 - books.google.com
Examining the chemical modification of biological polymers and the emerging applications
of this technology, Chemical Modification of Biological Polymers reflects the change in …
of this technology, Chemical Modification of Biological Polymers reflects the change in …
Physical and functional interaction sites in cytoplasmic domains of KCNQ1 and KCNE1 channel subunits
J Chen, Z Liu, J Creagh, R Zheng… - American Journal of …, 2020 - journals.physiology.org
The cardiac potassium I Ks current is carried by a channel complex formed from α-subunits
encoded by KCNQ1 and β-subunits encoded by KCNE1. Deleterious mutations in either …
encoded by KCNQ1 and β-subunits encoded by KCNE1. Deleterious mutations in either …