Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

The gill epithelium is the site of gas exchange, ionic regulation, acid-base balance, and
nitrogenous waste excretion by fishes. The last three processes are controlled by passive …

The'pump and leak" model of catioi~ transport was formally proposed by Tostesun and
Hoffman [l] in 1960 to explain the maintenance of cellular volume in animal cells. Over the …

The formation of bile depends on the structural and functional integrity of the bile-secretory
apparatus and its impairment, in different situations, results in the syndrome of cholestasis …

The physiological process of bile secretion has been studied extensively and is the subject
of many reviews (1-7). During the past few years, several new aspects have been explored …

Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological
importance, which plays essential roles in respiration, acid-base homeostasis, bone …

Organic anion transporting polypeptide (oatp) is an integral membrane protein cloned from
rat liver that mediates Na+-independent transport of organic anions such as …

Primary canalicular bile undergoes a process of fluidization and alkalinization along the
biliary tract that is influenced by several factors including hormones, innervation …

Several genetic mouse models of opiate sensitivity have been identified or produced in an
attempt to investigate mechanisms underlying individual variation in responses to opiate …

The distribution and physiologic role of carbonic anhydrase (CA) isozymes in the
mammalian alimentary tract have been widely investigated during the past decade. The …