Microbiome engineering for sustainable agriculture: using synthetic biology to enhance nitrogen metabolism in plant-associated microbes

SW Han, Y Yoshikuni - Current Opinion in Microbiology, 2022 - Elsevier
Highlights•Plant–microbe interactions are central to sustainable agriculture.•Nitrogen
metabolites play essential roles in plant-growth promotion.•Pyridoxal-5′-phosphate …

The tricarboxylic acid cycle as a central regulator of the rate of aging: implications for metabolic interventions

JM Borkum - Advanced Biology, 2023 - Wiley Online Library
Certain metabolic interventions such as caloric restriction, fasting, exercise, and a ketogenic
diet extend lifespan and/or health span. However, their benefits are limited and their …

PNO1 inhibits autophagy-mediated ferroptosis by GSH metabolic reprogramming in hepatocellular carcinoma

X Hu, Y He, Z Han, W Liu, D Liu, X Zhang, L Chen… - Cell death & …, 2022 - nature.com
Effective strategies for hepatocellular carcinoma, which is the second leading cause of death
worldwide, remain limited. A growing body of emerging evidence suggests that ferroptosis …

Microbial metabolic flexibility guarantees function resilience in response to starvation disturbance

YC Wang, YH Lv, XR Hu, YT Lin, JC Crittenden… - Bioresource …, 2024 - Elsevier
Starvation disturbance due to nutrient limitation is a common problem in bioreactors.
However, an understanding of how microbial systems respond to starvation remains in its …

Proteaphagy is specifically regulated and requires factors dispensable for general autophagy

KA Waite, A Burris, G Vontz, A Lang… - Journal of Biological …, 2022 - ASBMB
Changing physiological conditions can increase the need for protein degradative capacity in
eukaryotic cells. Both the ubiquitin-proteasome system and autophagy contribute to protein …

[HTML][HTML] Ethanol-lactate transition of Lachancea thermotolerans is linked to nitrogen metabolism

J Battjes, C Melkonian, SN Mendoza, A Haver… - Food …, 2023 - Elsevier
Climate change increases sugar content in grapes, resulting in unwanted increase in
ethanol content of wine. Lachancea thermotolerans ferments glucose and fructose into both …

[HTML][HTML] Autophagy–urea cycle pathway is essential for the statin-mediated nitric oxide bioavailability in endothelial cells

WH Chen, BC Guo, CH Chen, MC Hsu… - Journal of Food and …, 2023 - ncbi.nlm.nih.gov
Statins induce nitric oxide (NO) bioavailability by activating endothelial nitric oxide synthase
via kinase-and calcium-dependent pathways in endothelial cells (ECs). However, their effect …

The Change in Whole-Genome Methylation and Transcriptome Profile under Autophagy Defect and Nitrogen Starvation

Y Shi, B Yu, S Cheng, W Hu, F Liu - International Journal of Molecular …, 2023 - mdpi.com
Through whole-genome bisulfite sequencing and RNA-seq, we determined the potential
impact of autophagy in regulating DNA methylation in Arabidopsis, providing a solid …

Genome-wide CRISPR screening reveals nucleotide synthesis negatively regulates autophagy

K Mimura, JI Sakamaki, H Morishita, M Kawazu… - Journal of Biological …, 2021 - ASBMB
Macroautophagy (hereafter, autophagy) is a process that directs the degradation of
cytoplasmic material in lysosomes. In addition to its homeostatic roles, autophagy …

Antibacterial activity and mechanism of a novel bacteriocin produced by Lactiplantibacillus plantarum against Escherichia coli and Staphylococcus aureus

Z Xu, J Wang, W Zheng, S Zhao… - … Journal of Food …, 2023 - Wiley Online Library
The purpose of the study was to explore the antibacterial effect and mechanism of a novel
bacteriocin of Lactiplantibacillus plantarum (L. plantarum) against Escherichia coli (E. coli) …