Hepatic stellate cells (HSCs) are resident non-parenchymal liver pericytes whose plasticity
enables them to regulate a remarkable range of physiologic and pathologic responses. To …

Hepatic stellate cells (HSCs) comprise a minor cell population in the liver but serve
numerous critical functions in the normal liver and in response to injury. HSCs are primarily …

Liver fibrosis is a substantial risk factor for the development and progression of liver cancer,
which includes hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma …

Organoid technology provides a revolutionary paradigm toward therapy but has yet to be
applied in humans, mainly because of reproducibility and scalability challenges. Here, we …

The liver has been studied extensively due to the broad number of diseases affecting its vital
functions. However, therapeutic advances have been hampered by the lack of knowledge …

Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

Liver fibrosis, as an excess deposition of extracellular matrix (ECM) components, results
from chronic liver injury as well as persistent activation of inflammatory response and of …

Hepatic myofibroblasts are activated in response to chronic liver injury of any etiology to
produce a fibrous scar. Despite extensive studies, the origin of myofibroblasts in different …

Hepatic stellate cells are liver-specific mesenchymal cells that play vital roles in liver
physiology and fibrogenesis. They are located in the space of Disse and maintain close …

Hepatic fibrosis is a wound healing response to insults and as such affects the entire world
population. In industrialized countries, the main causes of liver fibrosis include alcohol …