Acute Trypanosoma cruzi infections can be asymptomatic, but chronically infected
individuals can die of Chagas' disease. The transfer of the parasite mitochondrial kinetoplast …

Antigenic variation allows African trypanosomes to develop chronic infections in mammalian
hosts. This process results from the alternative occurrence of transcriptional switching and …

Background Infection with Trypanosoma cruzi causes Chagas disease, a major public
health problem throughout Latin America. There is no vaccine and the only drugs have …

Trypanosomes are a group of protozoan eukaryotes, many of which are major parasites of
humans and livestock. The genomes of trypanosomes and their modes of gene expression …

Background Many components of the RNA polymerase II transcription machinery have been
identified in kinetoplastid protozoa, but they diverge substantially from other eukaryotes …

Background Trypanosoma cruzi uses several strategies to survive in different hosts. A key
step in the life-cycle of this parasite is metacyclogenesis, which involves various …

The protozoan parasite Trypanosoma cruzi, the etiologic agent of Chagas disease, is an
obligate intracellular protozoan pathogen. Overlapping mechanisms ensure successful …

Since the initial description of Trypanosoma cruzi by Carlos Chagas in 1909, several
research groups have used different microscopic techniques to obtain detailed information …

Trypanosomes are outstanding examples of the importance of mRNA metabolism in the
regulation of gene expression, as these unicellular eukaryotes mostly control protein …

Trypanosomes are ancient eukaryotic parasites in which the protein-coding genes,
organized in large polycistronic clusters on both strands, are transcribed from as yet …