The role of natural products in drug discovery and development against neglected tropical diseases

PM Cheuka, G Mayoka, P Mutai, K Chibale - Molecules, 2016 - mdpi.com
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually, including 875 million children in developing …

A review of anti-infective and anti-inflammatory chalcones

Z Nowakowska - European journal of medicinal chemistry, 2007 - Elsevier
Chalcones, considered as the precursors of flavonoids and isoflavonoids, are abundant in
edible plants, and have also been shown to display a diverse array of pharmacological …

Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence

L Chen, H Teng, Z Jia, M Battino, A Miron… - Critical reviews in …, 2018 - Taylor & Francis
Dietary flavonoids, which occur in many plant foods, are considered as the most active
constituents among the plant-derived ones in vitro and in vivo. To date, many studies have …

Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives

DK Mahapatra, SK Bharti, V Asati - European journal of medicinal chemistry, 2015 - Elsevier
In recent years, widespread outbreak of numerous infectious diseases across the globe has
created havoc among the population. Particularly, the inhabitants of tropical and sub-tropical …

Synthesis, reactions and application of chalcones: A systematic review

MA Shalaby, SA Rizk, AM Fahim - Organic & Biomolecular Chemistry, 2023 - pubs.rsc.org
Chalcones are a group of naturally occurring compounds that have biological effects that
include anti-inflammatory, anti-cancer, and antibacterial properties. Current chalcone …

Natural and synthetic 2′-hydroxy-chalcones and aurones: Synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity

A Detsi, M Majdalani, CA Kontogiorgis… - Bioorganic & medicinal …, 2009 - Elsevier
A series of 2′-hydroxy-chalcones and their oxidative cyclization products, aurones, have
been synthesized and tested for their antioxidant and lipoxygenase inhibitory activity. The …

A review of synthetic bioactive tetrahydro-β-carbolines: A medicinal chemistry perspective

J Wang, F Gong, T Liang, Z Xie, Y Yang, C Cao… - European Journal of …, 2021 - Elsevier
Abstract 1, 2, 3, 4-Tetrahydro-β-carboline (THβC) scaffold is widespread in many natural
products (NPs) and synthetic compounds which show a variety of pharmacological activities …

A comprehensive review of chalcone derivatives as antileishmanial agents

MVP de Mello, B de Azevedo Abrahim-Vieira… - European journal of …, 2018 - Elsevier
Leishmaniasis is a group of infectious neglected tropical diseases caused by more than 20
pathogenic species of Leishmania sp. Due to the limitations of the current treatments …

Addressing the quantitative conversion bottleneck in single-atom catalysis

Z Chen, J Song, R Zhang, R Li, Q Hu, P Wei… - Nature …, 2022 - nature.com
Single-atom catalysts (SACs) offer many advantages, such as atom economy and high
chemoselectivity; however, their practical application in liquid-phase heterogeneous …

Fruitful decade for antileishmanial compounds from 2002 to late 2011

H Hussain, A Al-Harrasi, A Al-Rawahi, IR Green… - Chemical …, 2014 - ACS Publications
Leishmaniasis, usually caused by the genus Leishmania, has not received the attention it
deserves and in recent times has developed into a major health problem worldwide. 1, 2 …