The role of natural products in drug discovery and development against neglected tropical diseases
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect
more than 1 billion people annually, including 875 million children in developing …
more than 1 billion people annually, including 875 million children in developing …
A review of anti-infective and anti-inflammatory chalcones
Z Nowakowska - European journal of medicinal chemistry, 2007 - Elsevier
Chalcones, considered as the precursors of flavonoids and isoflavonoids, are abundant in
edible plants, and have also been shown to display a diverse array of pharmacological …
edible plants, and have also been shown to display a diverse array of pharmacological …
Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence
Dietary flavonoids, which occur in many plant foods, are considered as the most active
constituents among the plant-derived ones in vitro and in vivo. To date, many studies have …
constituents among the plant-derived ones in vitro and in vivo. To date, many studies have …
Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives
In recent years, widespread outbreak of numerous infectious diseases across the globe has
created havoc among the population. Particularly, the inhabitants of tropical and sub-tropical …
created havoc among the population. Particularly, the inhabitants of tropical and sub-tropical …
Synthesis, reactions and application of chalcones: A systematic review
Chalcones are a group of naturally occurring compounds that have biological effects that
include anti-inflammatory, anti-cancer, and antibacterial properties. Current chalcone …
include anti-inflammatory, anti-cancer, and antibacterial properties. Current chalcone …
Natural and synthetic 2′-hydroxy-chalcones and aurones: Synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity
A Detsi, M Majdalani, CA Kontogiorgis… - Bioorganic & medicinal …, 2009 - Elsevier
A series of 2′-hydroxy-chalcones and their oxidative cyclization products, aurones, have
been synthesized and tested for their antioxidant and lipoxygenase inhibitory activity. The …
been synthesized and tested for their antioxidant and lipoxygenase inhibitory activity. The …
A review of synthetic bioactive tetrahydro-β-carbolines: A medicinal chemistry perspective
J Wang, F Gong, T Liang, Z Xie, Y Yang, C Cao… - European Journal of …, 2021 - Elsevier
Abstract 1, 2, 3, 4-Tetrahydro-β-carboline (THβC) scaffold is widespread in many natural
products (NPs) and synthetic compounds which show a variety of pharmacological activities …
products (NPs) and synthetic compounds which show a variety of pharmacological activities …
A comprehensive review of chalcone derivatives as antileishmanial agents
MVP de Mello, B de Azevedo Abrahim-Vieira… - European journal of …, 2018 - Elsevier
Leishmaniasis is a group of infectious neglected tropical diseases caused by more than 20
pathogenic species of Leishmania sp. Due to the limitations of the current treatments …
pathogenic species of Leishmania sp. Due to the limitations of the current treatments …
Addressing the quantitative conversion bottleneck in single-atom catalysis
Single-atom catalysts (SACs) offer many advantages, such as atom economy and high
chemoselectivity; however, their practical application in liquid-phase heterogeneous …
chemoselectivity; however, their practical application in liquid-phase heterogeneous …
Fruitful decade for antileishmanial compounds from 2002 to late 2011
Leishmaniasis, usually caused by the genus Leishmania, has not received the attention it
deserves and in recent times has developed into a major health problem worldwide. 1, 2 …
deserves and in recent times has developed into a major health problem worldwide. 1, 2 …