MYH9: Structure, functions and role of non-muscle myosin IIA in human disease

A Pecci, X Ma, A Savoia, RS Adelstein - Gene, 2018 - Elsevier
The MYH9 gene encodes the heavy chain of non-muscle myosin IIA, a widely expressed
cytoplasmic myosin that participates in a variety of processes requiring the generation of …

[HTML][HTML] Non-muscle myosin II takes centre stage in cell adhesion and migration

M Vicente-Manzanares, X Ma, RS Adelstein… - … reviews Molecular cell …, 2009 - nature.com
Non-muscle myosin II (NM II) is an actin-binding protein that has actin cross-linking and
contractile properties and is regulated by the phosphorylation of its light and heavy chains …

Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics

M Schmid, CN Toepfer - Biology open, 2021 - journals.biologists.com
The fundamental basis of muscle contraction 'the sliding filament model'(;) and the 'swinging,
tilting crossbridge-sliding filament mechanism'(;) nucleated a field of research that has …

Non-muscle myosin II in disease: mechanisms and therapeutic opportunities

KA Newell-Litwa, R Horwitz… - Disease models & …, 2015 - journals.biologists.com
The actin motor protein non-muscle myosin II (NMII) acts as a master regulator of cell
morphology, with a role in several essential cellular processes, including cell migration and …

Nonmuscle myosin II isoforms coassemble in living cells

JR Beach, L Shao, K Remmert, D Li, E Betzig… - Current Biology, 2014 - cell.com
Summary Nonmuscle myosin II (NM II) powers myriad developmental and cellular
processes, including embryogenesis, cell migration, and cytokinesis [1]. To exert its …

Cytoskeletal coordination during neuronal migration

BT Schaar, SK McConnell - Proceedings of the National …, 2005 - National Acad Sciences
Discoveries from human and mouse genetics have identified cytoskeletal and signaling
proteins that are essential for neuronal migration in the developing brain. To provide a …

[HTML][HTML] Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics

M Kneussel, W Wagner - Nature Reviews Neuroscience, 2013 - nature.com
Myosins are a large family of actin-based cytoskeletal motors that use energy derived from
ATP hydrolysis to generate movement and force. Myosins of classes II, V and VI have …

Nonmuscle myosin-2: mix and match

SM Heissler, DJ Manstein - Cellular and Molecular Life Sciences, 2013 - Springer
Members of the nonmuscle myosin-2 (NM-2) family of actin-based molecular motors
catalyze the conversion of chemical energy into directed movement and force thereby acting …

Mechanisms of actin stress fibre assembly

P Naumanen, P Lappalainen… - Journal of …, 2008 - Wiley Online Library
Stress fibres are contractile acto‐myosin structures found from many types of non‐muscle
cells, where they are involved in adhesion, motility and morphogenesis. Stress fibres …

Characterization of three full-length human nonmuscle myosin II paralogs

N Billington, A Wang, J Mao, RS Adelstein… - Journal of Biological …, 2013 - ASBMB
Nonmuscle myosin IIs (NM IIs) are a group of molecular motors involved in a wide variety of
cellular processes including cytokinesis, migration, and control of cell morphology. There …