[HTML][HTML] Chronic inflammation in the etiology of disease across the life span
Although intermittent increases in inflammation are critical for survival during physical injury
and infection, recent research has revealed that certain social, environmental and lifestyle …
and infection, recent research has revealed that certain social, environmental and lifestyle …
Immunosenescence and its hallmarks: how to oppose aging strategically? A review of potential options for therapeutic intervention
A Aiello, F Farzaneh, G Candore, C Caruso… - Frontiers in …, 2019 - frontiersin.org
Aging is accompanied by remodeling of the immune system. With time, this leads to a
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …
decline in immune efficacy, resulting in increased vulnerability to infectious diseases …
Chronic viral coinfections differentially affect the likelihood of developing long COVID
MJ Peluso, TM Deveau, SE Munter… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND The presence and reactivation of chronic viral infections, such as EBV,
CMV, and HIV, have been proposed as potential contributors to long COVID (LC), but …
CMV, and HIV, have been proposed as potential contributors to long COVID (LC), but …
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
Factors that influence the immune response to vaccination
P Zimmermann, N Curtis - Clinical microbiology reviews, 2019 - Am Soc Microbiol
There is substantial variation between individuals in the immune response to vaccination. In
this review, we provide an overview of the plethora of studies that have investigated factors …
this review, we provide an overview of the plethora of studies that have investigated factors …
The twilight of immunity: emerging concepts in aging of the immune system
J Nikolich-Žugich - Nature immunology, 2018 - nature.com
Immunosenescence is a series of age-related changes that affect the immune system and,
with time, lead to increased vulnerability to infectious diseases. This Review addresses …
with time, lead to increased vulnerability to infectious diseases. This Review addresses …
A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring
Immune responses generally decline with age. However, the dynamics of this process at the
individual level have not been characterized, hindering quantification of an individual's …
individual level have not been characterized, hindering quantification of an individual's …
Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOVER initiative
H Bonilla, MJ Peluso, K Rodgers, JA Aberg… - Frontiers in …, 2023 - frontiersin.org
Although most individuals recover from acute SARS-CoV-2 infection, a significant number
continue to suffer from Post-Acute Sequelae of SARS-CoV-2 (PASC), including the …
continue to suffer from Post-Acute Sequelae of SARS-CoV-2 (PASC), including the …
Standing on the shoulders of mice
K Medetgul-Ernar, MM Davis - Immunity, 2022 - cell.com
While inbred mice have informed most of what we know about the immune system in the
modern era, they have clear limitations with respect to their ability to be informative …
modern era, they have clear limitations with respect to their ability to be informative …