The ATP‐binding cassette (ABC) transporter superfamily comprises membrane proteins that
efflux various substrates across extra‐and intracellular membranes. Mutations in ABC genes …

In arbitrary dimension, in the discrete setting of finite-differences we prove a Carleman
estimate for a semi-discrete parabolic operator, in which the large parameter is connected to …

Here we describe the insights gained from sequencing the whole genomes of 2,636
Icelanders to a median depth of 20×. We found 20 million SNPs and 1.5 million insertions …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms and a large number of specific transporters have evolved to carry out this …

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder
characterized by maternal pruritus in the third trimester, raised serum bile acids and …

In this review we give an overview of the physiological functions of a group of ATP binding
cassette (ABC) transporter proteins, which were discovered, and still referred to, as …

Progressive familial intrahepatic cholestasis (PFIC) is a group of rare disorders which are
caused by defect in bile secretion and present with intrahepatic cholestasis, usually in …

C or impaired bile flow, is one of the most common and devastating manifestations of
hereditary and acquired liver diseases. Intrahepatic cholestasis of pregnancy (ICP) is a …

A number of liver disorders are specific to pregnancy. Amongst these, intrahepatic
cholestasis of pregnancy (ICP), also known as obstetric cholestasis (OC), is the commonest …

Abnormal liver tests occur in 3%–5% of pregnancies, with many potential causes, including
coincidental liver disease (most commonly viral hepatitis or gallstones) and underlying …