Itch: from mechanism to (novel) therapeutic approaches
G Yosipovitch, JD Rosen, T Hashimoto - Journal of allergy and clinical …, 2018 - Elsevier
Itch is a common sensory experience that is prevalent in patients with inflammatory skin
diseases, as well as in those with systemic and neuropathic conditions. In patients with …
diseases, as well as in those with systemic and neuropathic conditions. In patients with …
[HTML][HTML] Peripheral and central mechanisms of itch
X Dong, X Dong - Neuron, 2018 - cell.com
Itch is a unique sensory experience that is encoded by genetically distinguishable neurons
both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …
both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a …
Midcingulate cortex: structure, connections, homologies, functions and diseases
BA Vogt - Journal of chemical neuroanatomy, 2016 - Elsevier
Midcingulate cortex (MCC) has risen in prominence as human imaging identifies unique
structural and functional activity therein and this is the first review of its structure …
structural and functional activity therein and this is the first review of its structure …
Cutaneous barriers and skin immunity: differentiating a connected network
S Eyerich, K Eyerich, C Traidl-Hoffmann… - Trends in …, 2018 - cell.com
The skin is the outermost barrier of the organism that ensures protection from external harm.
Lately, our view of the skin has evolved from an inert mechanical barrier to an active organ …
Lately, our view of the skin has evolved from an inert mechanical barrier to an active organ …
Itch: Pathogenesis and treatment
Itch pathogenesis is broadly characterized into histaminergic and nonhistaminergic
pathways and transmitted via 2 main receptor families: G protein–coupled receptors and …
pathways and transmitted via 2 main receptor families: G protein–coupled receptors and …
A neuropeptide code for itch
ZF Chen - Nature Reviews Neuroscience, 2021 - nature.com
Itch is one of the most primal sensations, being both ubiquitous and important for the well-
being of animals. For more than a century, a desire to understand how itch is encoded by the …
being of animals. For more than a century, a desire to understand how itch is encoded by the …
[HTML][HTML] Neural correlates of evidence accumulation during value-based decisions revealed via simultaneous EEG-fMRI
Current computational accounts posit that, in simple binary choices, humans accumulate
evidence in favour of the different alternatives before committing to a decision. Neural …
evidence in favour of the different alternatives before committing to a decision. Neural …
[HTML][HTML] Central circuit mechanisms of itch
XJ Chen, YG Sun - Nature communications, 2020 - nature.com
Itch, in particular chronic forms, has been widely recognized as an important clinical
problem, but much less is known about the mechanisms of itch in comparison with other …
problem, but much less is known about the mechanisms of itch in comparison with other …
The vicious cycle of itch and anxiety
KM Sanders, T Akiyama - Neuroscience & Biobehavioral Reviews, 2018 - Elsevier
Chronic itch is associated with increased stress, anxiety, and other mood disorders. In turn,
stress and anxiety exacerbate itch, leading to a vicious cycle that affects patient behavior …
stress and anxiety exacerbate itch, leading to a vicious cycle that affects patient behavior …
[HTML][HTML] Tac1-expressing neurons in the periaqueductal gray facilitate the itch-scratching cycle via descending regulation
Uncontrollable itch-scratching cycles lead to serious skin damage in patients with chronic
itch. However, the neural mechanism promoting the itch-scratching cycle remains elusive …
itch. However, the neural mechanism promoting the itch-scratching cycle remains elusive …