Accelerating antiviral drug discovery: lessons from COVID-19
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and
collaborative drug discovery efforts took place in academia and industry, culminating in …
collaborative drug discovery efforts took place in academia and industry, culminating in …
Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells—overview and perspectives
X Cao, JP Coyle, R Xiong, Y Wang, RH Heflich… - In Vitro Cellular & …, 2021 - Springer
The lung is an organ that is directly exposed to the external environment. Given the large
surface area and extensive ventilation of the lung, it is prone to exposure to airborne …
surface area and extensive ventilation of the lung, it is prone to exposure to airborne …
Functional landscape of SARS-CoV-2 cellular restriction
L Martin-Sancho, MK Lewinski, L Pache, CA Stoneham… - Molecular cell, 2021 - cell.com
A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus …
(SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus …
Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19
C Tindle, MK Fuller, A Fonseca, S Taheri… - Elife, 2021 - elifesciences.org
Background: SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage
in the lungs in the setting of an overzealous immune response whose origin remains …
in the lungs in the setting of an overzealous immune response whose origin remains …
[HTML][HTML] Air-liquid interface (ALI) impact on different respiratory cell cultures
The intranasal route has been receiving greater attention from the scientific community not
only for systemic drug delivery but also for the treatment of pulmonary and neurological …
only for systemic drug delivery but also for the treatment of pulmonary and neurological …
Gene therapy for cystic fibrosis: new tools for precision medicine
The discovery of the Cystic fibrosis (CF) gene in 1989 has paved the way for incredible
progress in treating the disease such that the mean survival age of individuals living with CF …
progress in treating the disease such that the mean survival age of individuals living with CF …
[HTML][HTML] In vitro and ex vivo models in inhalation biopharmaceutical research—advances, challenges and future perspectives
Oral inhalation results in pulmonary drug targeting and thereby reduces systemic side
effects, making it the preferred means of drug delivery for the treatment of respiratory …
effects, making it the preferred means of drug delivery for the treatment of respiratory …
A 96-well format microvascularized human lung-on-a-chip platform for microphysiological modeling of fibrotic diseases
Development of organoids and microfluidic on-chip models has enabled studies of organ-
level disease pathophysiologies in vitro. However, current lung-on-a-chip platforms are …
level disease pathophysiologies in vitro. However, current lung-on-a-chip platforms are …
Biofilm aggregates and the host airway-microbial interface
L Hall-Stoodley, KS McCoy - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Biofilms are multicellular microbial aggregates that can be associated with host mucosal
epithelia in the airway, gut, and genitourinary tract. The host environment plays a critical role …
epithelia in the airway, gut, and genitourinary tract. The host environment plays a critical role …
Recent advances in human respiratory epithelium models for drug discovery
The respiratory epithelium is intimately associated with the pathophysiologies of highly
infectious viral contagions and chronic illnesses such as chronic obstructive pulmonary …
infectious viral contagions and chronic illnesses such as chronic obstructive pulmonary …