Alterations in α-synuclein dosage lead to familial Parkinson's disease (PD), and its
accumulation results in synucleinopathies that include PD, dementia with Lewy bodies …

Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

The histopathological hallmark of Parkinson's disease (PD) is the presence of fibrillar
aggregates referred to as Lewy bodies (LBs), in which α-synuclein is a major constituent …

The pathological aggregation of the presynaptic protein α-synuclein (α-syn) and propagation
through synaptically coupled neuroanatomical tracts is increasingly thought to underlie the …

The histological hallmark of Parkinson's disease (PD) is the presence of fibrillar aggregates
called Lewy bodies (LBs). LB formation has been considered to be a marker for neuronal …

Multiple system atrophy (MSA) is an orphan, fatal, adult-onset neurodegenerative disorder of
uncertain etiology that is clinically characterized by various combinations of parkinsonism …

Amphisomes are intermediate/hybrid organelles produced through the fusion of endosomes
with autophagosomes within cells. Amphisome formation is an essential step during a …

Aggregation of α‐synuclein, an abundant and conserved pre‐synaptic brain protein, is
implicated as a critical factor in several neurodegenerative diseases. These diseases …

Pathology consisting of intracellular aggregates of alpha-Synuclein (α-Syn) spread through
the nervous system in a variety of neurodegenerative disorders including Parkinson's …

Multiple system atrophy (MSA) is a sporadic and rapidly progressive neurodegenerative
disorder that presents with autonomic failure in combination with parkinsonism or cerebellar …