Many questions have been posed about acquired immunodeficiency syndrome (AIDS)
pathogenesis. Is human immunodeficiency virus (HIV) both necessary and sufficient to …

Soon after HIV was discovered as the cause of AIDS in 1983–1984, there was an
expectation that a preventive vaccine would be rapidly developed. In trying to achieve that …

A blood donor infected with human immunodeficiency virus-type 1 (HIV-1) and a cohort of
six blood or blood product recipients infected from this donor remain free of HIV-1-related …

Background In most subjects infected with human immunodeficiency virus type 1 (HIV-1),
clinical or laboratory evidence of immunodeficiency develops within 10 years of …

Some HIV-1–infected patients develop broad and potent HIV-1 neutralizing antibodies
(bNAbs) that when passively transferred to mice or macaques can treat or prevent infection …

To gain more insight into the role of HIV-1-specific cytotoxic T lymphocytes (CTL) in the
pathogenesis of AIDS, we investigated temporal relations between HIV-1 Gag-specific …

Background and Methods The Sydney Blood Bank Cohort consists of a blood donor and
eight transfusion recipients who were infected before 1985 with a strain of human …

Considerable progress has been made recently in understanding the genetic, immunologic,
and virologic factors in human immunodeficiency virus (HIV)-infected individuals who either …

Some individuals in well-defined cohorts have now been infected with HIV-1 for well over a
decade and yet remain clinically asymptomatic with normal CD4 counts. To determine …

The discovery of highly divergent strains of human immunodeficiency virus (HIV) not reliably
detected by a number of commonly used diagnostic tests has underscored the need for …