Considering sex as a biological variable in basic and clinical studies: an endocrine society scientific statement

A Bhargava, AP Arnold, DA Bangasser… - Endocrine …, 2021 - academic.oup.com
Abstract In May 2014, the National Institutes of Health (NIH) stated its intent to “require
applicants to consider sex as a biological variable (SABV) in the design and analysis of NIH …

[HTML][HTML] The impact of biological sex on diseases of the urinary tract

L Deltourbe, LL Mariano, TN Hreha, DA Hunstad… - Mucosal …, 2022 - Elsevier
Biological sex, being female or male, broadly influences diverse immune phenotypes,
including immune responses to diseases at mucosal surfaces. Sex hormones, sex …

The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias

MJ Curtis, JC Hancox, A Farkas, CL Wainwright… - Pharmacology & …, 2013 - Elsevier
The 'Lambeth Conventions' is a guidance document, written in 1987 (Walker et al., 1988),
intended to be of practical value in the investigation of experimental arrhythmias induced by …

Sex hormones affect outcome in arrhythmogenic right ventricular cardiomyopathy/dysplasia: from a stem cell derived cardiomyocyte-based model to clinical …

D Akdis, AM Saguner, K Shah, C Wei… - European heart …, 2017 - academic.oup.com
Aims Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is characterized
by fibrofatty infiltration of the myocardium and ventricular arrhythmias that may lead to …

Complex actions of sex steroids in adipose tissue, the cardiovascular system, and brain: Insights from basic science and clinical studies

JL Turgeon, MC Carr, PM Maki… - Endocrine …, 2006 - academic.oup.com
Recent publications describing the results of the Women's Health Initiative (WHI) and other
studies reporting the impact of hormone therapy on aging women have spurred …

Unexpected plasma gonadal steroid and prolactin levels across the mouse estrous cycle

EG Wall, R Desai, Z Khant Aung, SH Yeo… - …, 2023 - academic.oup.com
Despite the importance of the mouse in biomedical research, the levels of circulating
gonadal steroids across the estrous cycle are not established with any temporal precision …

[HTML][HTML] Recent advances in understanding sex differences in cardiac repolarization

AF James, SCM Choisy, JC Hancox - Progress in biophysics and molecular …, 2007 - Elsevier
A number of gender differences exist in the human electrocardiogram (ECG): the P-wave
and PR intervals are slightly longer in men than in women, whilst women have higher …

Male-specific IL-33 expression regulates sex-dimorphic EAE susceptibility

AE Russi, ME Ebel, Y Yang… - Proceedings of the …, 2018 - National Acad Sciences
The cellular and molecular basis of sex-dimorphic autoimmune diseases, such as the CNS
demyelinating disease multiple sclerosis (MS), remains unclear. Our studies in the SJL …

Sex differences in mechanisms of cardiac excitation–contraction coupling

RJ Parks, SE Howlett - Pflügers Archiv-European Journal of Physiology, 2013 - Springer
The incidence and expression of cardiovascular diseases differs between the sexes. This is
not surprising, as cardiac physiology differs between men and women. Clinical and basic …

Human LH and hCG stimulate differently the early signalling pathways but result in equal testosterone synthesis in mouse Leydig cells in vitro

L Riccetti, F De Pascali, L Gilioli, F Potì, LB Giva… - Reproductive Biology …, 2017 - Springer
Background Human luteinizing hormone (LH) and chorionic gonadotropin (hCG) are
glycoprotein hormones regulating development and reproductive functions by acting on the …