Alpha (α)-thalassemia is a blood disorder caused by many types of inheritable α-globin
gene mutations which causes no-to-severe clinical symptoms, such as Hb Bart's hydrops …

Background Suboptimal glycemic control among patients with type 2 diabetes mellitus (DM)
is a significant public health problem, particularly among people living with poor education …

Data on hemoglobin (Hb) variants in southern Thailand are lacking. This study aimed to
reassess the frequency of Hb variants and the clinical aspects of compound heterozygous …

Hemoglobin Shaare Zedek (Hb SZ) is a rare structural α-Hb variant. Characterizing its
genotype–phenotype relationship and genetic origin enhances diagnostic and clinical …

Objective In the present study, two unrelated cases of Hb Q-Thailand heterozygosity
unlinked with the (–α4. 2/) α+-thalassemia deletion allele were identified by long-read single …

Background Rare and novel variants of HBA1/2 and HBB genes resulting in thalassemia
and hemoglobin (Hb) variants have been increasingly identified. Our goal was to identify two …

Background An increasing number of α-hemoglobin (Hb) variants is causing various clinical
symptoms; therefore, accurate identification of these Hb variants is important. Objective This …

Abstract Hemoglobin (Hb) H/Constant Spring disease is a common nondeletional Hb H
disease, typically causing a more severe phenotype than the deletional Hb H disease …

Adenine base editing offers a viable gene-based therapy for sickle cell disease (SCD),
converting sickle hemoglobin (HbS, βΕ6V) to G-Makassar hemoglobin (HbG, βE6A), a …

Interaction of structural hemoglobin (Hb) variants with α-or β-globin defects are occasional in
Southeast Asia. Herein we provide the first description of Hb Athens-Georgia (Hb A-Ga) in …