RNA-based therapies, including RNA molecules as drugs and RNA-targeted small
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …

Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …

The origin of life is a fascinating, unresolved problem whose deciphering would have
important scientific, epistemological and social implications. Over time, philosophers and …

The microbial mechanisms and key metabolites that shape the composition of the human
gut microbiota are largely unknown, impeding efforts to manipulate dysbiotic microbial …

Sensors are devices that respond to physical or chemical stimuli and produce detectable
signals. 1r4 They are a critical extension of human perception of the world in many aspects …

The term non-coding RNA (ncRNA) is commonly employed for RNA that does not encode a
protein, but this does not mean that such RNAs do not contain information nor have function …

Background To understand an RNA sequence's mechanism of action, the structure must be
known. Furthermore, target RNA structure is an important consideration in the design of …

The structures of RNA molecules are often important for their function and regulation,,,,,, yet
there are no experimental techniques for genome-scale measurement of RNA structure …

With an increasing interest in RNA therapeutics and for targeting RNA to treat disease, there
is a need for the tools used in protein-based drug design, particularly DOCKing algorithms …

One of the fundamental issues in RNA splicing research is represented by understanding
how the spliceosome can successfully define exons and introns in a huge variety of pre …