Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways
involved in numerous physiological processes (eg, vasodilation, neurotransmission …

Reactive oxygen species and reactive nitrogen species are biological molecules that play
important roles in cardiovascular physiology and contribute to disease initiation …

Glutathione plays many important roles in biological processes; however, the dynamic
changes of glutathione concentrations in living cells remain largely unknown. Here, we …

Protein oxidative modifications, also known as protein oxidation, are a major class of protein
posttranslational modifications. They are caused by reactions between protein amino acid …

Delivering and expressing a gene of interest in cells or living animals has become a pivotal
technique in biomedical research and gene therapy. Among viral delivery systems, adeno …

It is now well established that reactive oxygen species (ROS), reactive nitrogen species
(RNS), and a basal level of oxidative stress are essential for cell survival. It is also well …

Significance: Over the past several years, oxidative post-translational modifications of
protein cysteines have been recognized for their critical roles in physiology and …

Glutathione (GSH) is the most abundant antioxidant and a major detoxification agent in cells.
It is synthesized through two-enzyme reaction catalyzed by glutamate cysteine ligase and …

Reactive oxygen species (ROS) are key signaling molecules that regulate vascular function
and structure in physiological conditions. A misbalance between the production and …

To investigate the effects of the predominant nonprotein thiol, glutathione (GSH), on redox
homeostasis, we employed complementary pharmacological and genetic strategies to …