Have mRNA vaccines sentenced DNA vaccines to death?

A Cagigi, B Douradinha - Expert Review of Vaccines, 2023 - Taylor & Francis
Introduction After receiving emergency approval during the COVID-19 pandemic, mRNA
vaccines have taken center stage in the quest to enhance future vaccination strategies for …

Potential of mRNA-based vaccines for the control of tick-borne pathogens in one health perspective

E González-Cueto, J De La Fuente… - Frontiers in …, 2024 - frontiersin.org
The One Health approach, which integrates the health of humans, animals, plants, and
ecosystems at various levels, is crucial for addressing interconnected health threats. This is …

PEDV-spike-protein-expressing mRNA vaccine protects piglets against PEDV challenge

Y Zhao, B Fan, X Song, J Gao, R Guo, C Yi, Z He, H Hu… - Mbio, 2024 - Am Soc Microbiol
Porcine epidemic diarrhea virus (PEDV), a swine enteropathogenic coronavirus, causes
severe diarrhea in neonatal piglets, which is associated with a high mortality rate. Thus …

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

L Huang, T Zhao, W Zhao, A Shao, H Zhao… - Emerging Microbes & …, 2024 - Taylor & Francis
Herpes zoster remains an important global health issue and mainly occurs in aged and
immunocompromised individuals with an early exposure history to Varicella Zoster Virus …

Circular RNA vaccines with long-term lymph node-targeting delivery stability after lyophilization induce potent and persistent immune responses

J Wan, Z Wang, L Wang, L Wu, C Zhang, M Zhou… - Mbio, 2024 - Am Soc Microbiol
Several recent attempts to improve the stability and immunogenicity of messenger RNA
(mRNA) vaccines include the use of circular RNA (circRNA), targeted delivery, and …

A single immunization with core–shell structured lipopolyplex mRNA vaccine against rabies induces potent humoral immunity in mice and dogs

J Wan, J Yang, Z Wang, R Shen, C Zhang… - Emerging Microbes & …, 2023 - Taylor & Francis
The persistence and clinical consequences of rabies virus (RABV) infection have prompted
global efforts to develop a safe and effective vaccines against rabies. mRNA vaccines …

A modified recombinant adenovirus vector containing dual rabies virus G expression cassettes confers robust and long-lasting humoral immunity in mice, cats, and …

Y Zhang, L Fang, Z Wang, C Zhang, J Zhao… - Emerging Microbes & …, 2024 - Taylor & Francis
During the COVID-19 epidemic, the incidence of rabies has increased in several countries,
especially in remote and disadvantaged areas, due to inadequate surveillance and …

Single-injection subunit vaccine for rabies prevention using lentinan as adjuvant

X Zhou, H Wang, J Zhang, Y Guan, Y Zhang - International Journal of …, 2024 - Elsevier
Current rabies vaccines require 5 doses to provide full protection from the deadly virus,
which significantly reduce the compliance of recipients. To minimize the number of …

A rabies mRNA vaccine provides a rapid and long-term immune response in mice

J Long, C Yu, Y Cao, Y Miao, H Sun, Z Zhang, J Mai… - Nano Today, 2023 - Elsevier
Rabies is a fatal viral disease caused by the rabies virus (RABV), with a case fatality rate in
humans of almost 100%. Vaccinations are the most effective method of preventing and …

[HTML][HTML] Modulation of innate immune response to mRNA vaccination after SARS-CoV-2 infection or sequential vaccination in humans

F Hellgren, A Rosdahl, RA Cerveira, K Lenart, S Ols… - JCI insight, 2024 - ncbi.nlm.nih.gov
Abstract mRNA vaccines are likely to become widely used for the prevention of infectious
diseases in the future. Nevertheless, a notable gap exists in mechanistic data, particularly …