BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

During pregnancy, development of the placenta is interrelated with the oxygen
concentration. Embryo development takes place in a low oxygen environment until the …

Preeclampsia is a pregnancy-associated disorder characterized by hypertension, and could
lead to maternal and fetal morbidity and mortality; however, the pathophysiological …

Background—Preeclampsia is characterized clinically by hypertension and proteinuria.
Soluble Flt-1 (sFlt-1; also known as soluble vascular endothelial growth factor receptor-1 …

Active and passive maternal smoking has a damaging effect in every trimester of human
pregnancy. Cigarette smoke contains scores of toxins which exert a direct effect on the …

Malperfusion of the placenta has been implicated as a cause of oxidative stress in
complications of human pregnancy, leading to release of proinflammatory cytokines and anti …

Pre-eclampsia is a pregnancy-specific hypertensive disorder that may lead to serious
maternal and fetal complications. It is a multisystem disease that is commonly, but not …

Preeclampsia is a potentially fatal complication of human pregnancy characterized by
hypertension, proteinuria, and edema. Placental oxidative stress is a key element in the …

The syncytiotrophoblast (STB) that forms the epithelial covering of the placental villous tree
has a unique cell biology on account of its syncytial nature. The tissue is in a terminally …

Preeclampsia is a complex hypertensive disorder in pregnancy which can be lethal and is
responsible for more than 70,000 maternal deaths worldwide every year. Besides the higher …