Background Animal studies and trials in older children and adults suggest that a'one dose
per day'regimen of gentamicin is superior to a'multiple doses per day'regimen. Objectives To …

Aminoglycosides constitute one of the oldest classes of antimicrobials. Despite their toxicity,
mainly nephrotoxicity and ototoxicity, aminoglycosides are valuable in current clinical …

ABSTRACT A pharmacokinetic-pharmacodynamic (PKPD) model that characterizes the full
time course of in vitro time-kill curve experiments of antibacterial drugs was here evaluated …

Quantifying the uncertainty around endpoints used for decision-making in drug development
is essential. In nonlinear mixed-effects models (NLMEM) analysis, this uncertainty is derived …

Linked Articles This article is commented on in the editorial by Holford NHG and Anderson
BJ. Why standards are useful for predicting doses. Br J Clin Pharmacol 2017; 83: 685–7. doi …

Antibiotic stewardship programmes aim to optimise antimicrobial use to prevent the
emergence of resistance species and protect patients from the side effects of unnecessary …

Population pharmacokinetic modelling is widely used within the field of clinical
pharmacology as it helps to define the sources and correlates of pharmacokinetic variability …

Neonatal sepsis remains an important cause of morbidity and mortality in neonatal intensive
care units (NICUs). Accordingly, antibiotics are frequently prescribed, with ampicillin …

Only anecdotal data are available on the pharmacokinetics (PK) of miltefosine in children
suffering from visceral leishmaniasis (VL). While failure rates were higher in children with …

Abstract Background and Objectives During the newborn period and early infancy, renal
function matures, resulting in changes in the glomerular filtration rate (GFR). This study was …