Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …

Chronic pain affects more than 50 million Americans. Treatments remain inadequate, in
large part, because the pathophysiological mechanisms underlying the development of …

Complex regional pain syndrome (CRPS) is a pain condition that usually affects a single
limb, often following an injury. The underlying pathophysiology seems to be complex and …

Chronic pain is a major public health issue with an incidence of 20–25% worldwide that can
take different forms like neuropathic, cancer-related or inflammatory pain. Chronic pain often …

Abstract Purpose of Review This review presents the most current information about the
epidemiology of complex regional pain syndrome (CRPS), classification and diagnostic …

Accumulating evidence suggests that epigenetic mechanisms may hold great potential in
the field of pain. We systematically reviewed the literature exploring epigenetic mechanisms …

Abstract Background Rapid-acting antidepressants (RAADs), including dissociative
anesthetics, psychedelics, and empathogens, elicit rapid and sustained therapeutic …

Complex regional pain syndrome (CRPS) is characterized by continuous pain that is often
accompanied by sensory, motor, vasomotor, sudomotor, and trophic disturbances. If left …

Chronic pain is a major public health problem and an economic burden worldwide.
However, its underlying pathological mechanisms remain unclear. MicroRNAs (miRNAs) are …

Neuro-immune alterations in the peripheral and central nervous system play a role in the
pathophysiology of chronic pain in general, and members of the non-coding RNA (ncRNA) …